| A water-soluble BODIPY derivative as a highly selective "Turn-On" fluorescent sensor for H2O2 sensing in vivo | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Xu J(徐健)1,2,3 ; Li Q(李欠)1,2; Yue Y(岳莹)1,2; Guo Y(郭勇)1,2; Shao SJ(邵士俊)1,2; Shao SJ(邵士俊)
| |
| 2014 | |
| Source Publication | Biosensors and Bioelectronics
 |
| ISSN | 0956-5663 |
| Volume | 56Pages:58-63 |
| Abstract | A type of BODIPY derivatives was designed and synthesized by the N-alkylation reaction of meso-(4-pyridinyl)-substituted BODIPY. The water-solubility of entire molecule was improved to a large extent as a result of the formation of cationic quaternary ammonium salt, while the strong fluorescence inherent to the BODIPY dye fragment is extinguished on alkylation of the pyridine N atom due to the photo- induced electron transfer (PET) process. The N-alkylated BODIPY derivative 4, as a novel water-soluble “Turn-On” fluorescent probe for the discrimination of H2O2, was constructed by incorporating 4-(Bromomethyl)benzeneboronic acid pinacol ester moiety, which showed highly selective fluorescent response to H2O2 against other interferences of ROS and RNS species under physiological conditions, and the reaction mechanism of boronate oxidation was confirmed by 1H NMR, mass spectrum and optical spectroscopy analysis. As a biocompatible probe in biological systems, probe 4 was successfully applied for monitoring and imaging of H2O2 both in vitro and in vivo using HepG2/LO2 cells and angelfish. |
| Keyword | N-alkylpyridinium Substituted Bodipy Derivatives Water-soluble Fluorescent Probe Fluorescent Sensor H2o2 In Vitro And In Vivo imagIng |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.bios.2013.12.065 |
| Funding Organization | the National Natural Science Foundation of China (20972170;21275150);the Funds for Distinguished Young Scientists of Gansu (1210RJDA013);the Natural Science Foundation of Gansu province (1107RJYA069) |
| Indexed By | SCI |
| If | 6.409 |
| Language | 英语 |
| Funding Project | 药物分子识别研究组;药物分离材料研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/7099 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Shao SJ(邵士俊) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| Recommended Citation GB/T 7714 | Xu J,Li Q,Yue Y,et al. A water-soluble BODIPY derivative as a highly selective "Turn-On" fluorescent sensor for H2O2 sensing in vivo[J]. Biosensors and Bioelectronics,2014,56:58-63. |
| APA | Xu J,Li Q,Yue Y,Guo Y,Shao SJ,&邵士俊.(2014).A water-soluble BODIPY derivative as a highly selective "Turn-On" fluorescent sensor for H2O2 sensing in vivo.Biosensors and Bioelectronics,56,58-63. |
| MLA | Xu J,et al."A water-soluble BODIPY derivative as a highly selective "Turn-On" fluorescent sensor for H2O2 sensing in vivo".Biosensors and Bioelectronics 56(2014):58-63. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 徐健2014-1.pdf（2827KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment