Potential Anti-Tumor Activity of Nardoguaianone L Isolated from Nardostachys jatamansi DC. in SW1990 Cells | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Chun-Yan Sang1; Yi-Dan Zheng2; Li-Mei Ma1,3; Li-Mei Ma1,3; Cheng-Bo Wang1; Tian Chai1; Komila A. Eshbakova4; Jun-Li Yang1 | |
The second department | 药物化学与新药分子研究团队 |
2022-11-03 | |
Source Publication | Molecules |
Volume | 21Issue:27Pages:7490 |
Abstract | Natural products (NPs) were a rich source of diverse bioactive molecules. Most anti-tumor agents were built on natural scaffolds. Nardostachys jatamansi DC. was an important plant used to process the traditional Chinese herbal medicines “gansong”. Pancreatic cancer was the fourth most common cause of cancer-related death in the world. Hence, there was an urgent need to develop novel agents for the treatment of pancreatic cancer. In this paper, nardoguaianone L (G-6) is isolated from N. jatamansi, which inhibited SW1990 cells colony formation and cell migration, and induced cell apoptosis. Furthermore, we analyzed the differential expression proteins after treatment with G-6 in SW1990 cells by using iTRAQ/TMT-based quantitative proteomics technology, and the results showed that G-6 regulated 143 proteins’ differential expression by GO annotation, including biological process, cellular component, and molecular function. Meanwhile, KEGG enrichment found that with Human T-cell leukemia virus, one infection was the most highly enhanced pathway. Furthermore, the MET/PTEN/TGF-β pathway was identified as a significant pathway that had important biological functions, including cell migration and motility by PPI network analysis in SW1990 cells. Taken together, our study found that G-6 is a potential anti-pancreatic cancer agent with regulation of MET/PTEN/TGF-β pathway. |
Keyword | natural products Nardostachys jatamansi DC. pancreatic cancer iTRAQ/TMT MET/PTEN/TGF-β pathway |
DOI | 10.3390/molecules27217490 |
If | 4.927 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/29564 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Affiliation | 1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS) 2.College of Life Science, Northwest Normal University 3.Beijing Research Institute, University of Chinese Academy of Sciences 4.S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences |
Recommended Citation GB/T 7714 | Chun-Yan Sang,Yi-Dan Zheng,Li-Mei Ma,et al. Potential Anti-Tumor Activity of Nardoguaianone L Isolated from Nardostachys jatamansi DC. in SW1990 Cells[J]. Molecules,2022,21(27):7490. |
APA | Chun-Yan Sang.,Yi-Dan Zheng.,Li-Mei Ma.,Li-Mei Ma.,Cheng-Bo Wang.,...&Jun-Li Yang.(2022).Potential Anti-Tumor Activity of Nardoguaianone L Isolated from Nardostachys jatamansi DC. in SW1990 Cells.Molecules,21(27),7490. |
MLA | Chun-Yan Sang,et al."Potential Anti-Tumor Activity of Nardoguaianone L Isolated from Nardostachys jatamansi DC. in SW1990 Cells".Molecules 21.27(2022):7490. |
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