Caffeic acid derivatives as growth inhibitor to Setaria viridis: structure-activity relationships and mechanisms | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Li XZ(李秀壮)1; Yan ZQ(燕志强)1; Pan L(潘乐)1,2; Jin H(金辉)1; Yang XY(杨晓燕)1; Jun-de Liu3; Xiaofeng He(何小凤)1; Xia Ren(任夏)1,2; Kai Guo(郭凯)1,2; Qin B(秦波)1 | |
2017 | |
Source Publication | Phytochemistry Letters |
Issue | 20Pages:208-213 |
Abstract | Weeds bring severe threats to agricultural production and most traditional herbicides cause serious pollution to the environment. Caffeic acid is a potential allelochemical of many crops. To develop novel herbicides, a series of trans-caffeic acid analogues were prepared to evaluate their growth inhibition on S. viridis and investigate structure-activity relationships. Presence of hydroxyl groups on the benzene ring greatly reduced the phytotoxicity of analogues and the double bond seemed not to be necessary. Moreover, it was found that halogenated cinnamic acid analogues showed potent inhibitory activity. 4-Fluorocinnamic acid (4-FCA) displayed the strongest growth inhibition in a concentration-dependent manner, whereas it induced significantly weaker inhibition on wheat. This selectivity could help us to develop a novel herbicide. Exposure of S. viridis to 4-FCA increased levels of H2O2 and catalase (CAT) in roots, suggesting that the inhibitory effect of 4-FCA might be related to oxidative stress. Thus, we have found an active lead compound for a novel herbicide derived from crop allelochemicals, which may help in the development of new environmentally safe herbicides. |
Keyword | Caffeic Acid 4-fluorocinnamic Acid Analogues Phytotoxicity Structure-activity Relationships Mechanisms |
MOST Discipline Catalogue | 植物化学生态研究 |
DOI | 10.1016/j.phytol.2017.04.041 |
If | 1.575 |
Language | 英语 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/24721 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Qin B(秦波) |
Affiliation | 1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences, Lanzhou 730000, China 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.Lanzhou station of Agricultural management and guidance, Lanzhou 730030, China |
Recommended Citation GB/T 7714 | Li XZ,Yan ZQ,Pan L,et al. Caffeic acid derivatives as growth inhibitor to Setaria viridis: structure-activity relationships and mechanisms[J]. Phytochemistry Letters,2017(20):208-213. |
APA | Li XZ.,Yan ZQ.,Pan L.,Jin H.,Yang XY.,...&Qin B.(2017).Caffeic acid derivatives as growth inhibitor to Setaria viridis: structure-activity relationships and mechanisms.Phytochemistry Letters(20),208-213. |
MLA | Li XZ,et al."Caffeic acid derivatives as growth inhibitor to Setaria viridis: structure-activity relationships and mechanisms".Phytochemistry Letters .20(2017):208-213. |
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