Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l

doi:10.3390/molecules23102663

LICP OpenIR > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l
Department	中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
	Tian Chai 1; Xiao-Bo Zhao 2; Wei-Feng Wang 2; Yin Qiang 1; Xiao-Yun Zhang 1; Jun-Li Yang2
	2018
Source Publication	Molecules
Volume	23 Issue:10 Pages:2663
Abstract	Gx-50 is a bioactive compound for the treatment of Alzheimer’s disease (AD) found in Sichuan pepper (Zanthoxylum bungeanum). In order to find a stronger anti-AD lead compound, 20 gx-50 (1–20) analogs have been designed and synthesized, and their molecular structures were determined based on nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis, as well as comparison with literature data. Compounds 1–20 were evaluated for their anti-AD potential by using DPPH radical scavenging assay for considering their anti-oxidant activity, thioflavin T (ThT) fluorescence assay for considering the inhibitory or disaggregate potency of Aβ, and transgenic Drosophila model assay for evaluating their rescue effect on memory loss. Finally, compound 13 was determined as a promising anti-AD candidate.
Keyword	Alzheimer’s Disease Gx-50 Dpph Assay Tht Assay Transgenic Drosophila Model Assay
MOST Discipline Catalogue	理学::化学
DOI	10.3390/molecules23102663
If	3.098
Language	英语
compositor	第二作者单位
Citation statistics	Cited Times:8[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/24247
Collection	中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
Corresponding Author	Jun-Li Yang
Affiliation	1.Lanzhou University 2.Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences (CAS)
Recommended Citation GB/T 7714	Tian Chai,Xiao-Bo Zhao,Wei-Feng Wang,等. Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l[J]. Molecules,2018,23(10):2663.
APA	Tian Chai,Xiao-Bo Zhao,Wei-Feng Wang,Yin Qiang,Xiao-Yun Zhang,&Jun-Li Yang.(2018).Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l.Molecules,23(10),2663.
MLA	Tian Chai,et al."Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory l".Molecules 23.10(2018):2663.

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