Direct preparation of a graphene oxide modified monolith in a glass syringe as a solid-phase extraction cartridge for the extraction of quaternary ammonium alkaloids from Chinese patent medicine | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Liang XJ(梁晓静); Wang LC(王立成); Wang S(王帅); Li YJ(李亦婧); Guo Y(郭勇); Guo Y(郭勇); Wang LC(王立成) | |
2017 | |
Source Publication | Journal of Separation Science |
ISSN | 1615-9306 |
Volume | 40Issue:22Pages:4411-4419 |
Abstract | Packed cartridges have been widely used in solid‐phase extraction. However, there are still some drawbacks, such as they are blocked easily and the method is time‐consuming. In view of the advantages of monoliths, a monolithic extraction material has been directly synthesized in a glass syringe without any gap between the monolith and syringe inner wall. The monolithic syringe was modified with graphene oxide by loading graphene oxide dispersion onto it. The content of graphene oxide and the surface topography of the monolith have been evaluated by elemental analysis and scanning electron microscopy, respectively, which confirmed the successful modification. This prepared graphene oxide‐modified monolithic syringe was directly used as a traditional solid‐phase extraction cartridge. As expected, it shows good permeability and excellent capability for the extraction of quaternary ammonium alkaloids. The sample loading velocity (1–6 mL/min) does not affect the recovery. Under the optimal conditions, good linearities (R = 0.9992–0.9998) were obtained for five quaternary ammonium alkaloids, and the limits of detection and quantification were 0.5‐1 and 1–2 μg/L, respectively. The proposed method was successfully applied for the analysis of quaternary ammonium alkaloids in Chinese patent medicine. |
Keyword | Graphene Oxide Monolithic Syringe Quaternary Ammonium Alkaloids Solid-phase Extraction |
Subject Area | 分析化学与药物化学 |
DOI | 10.1002/jssc.201700856 |
Funding Organization | the National Natural Science Foundation of China (Nos. 21475143;21575148;21575149);the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2015344) |
Indexed By | SCI |
Language | 英语 |
Funding Project | 药物分离材料研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/23812 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Guo Y(郭勇); Wang LC(王立成) |
Affiliation | CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for NaturalMedicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China |
Recommended Citation GB/T 7714 | Liang XJ,Wang LC,Wang S,et al. Direct preparation of a graphene oxide modified monolith in a glass syringe as a solid-phase extraction cartridge for the extraction of quaternary ammonium alkaloids from Chinese patent medicine[J]. Journal of Separation Science,2017,40(22):4411-4419. |
APA | Liang XJ.,Wang LC.,Wang S.,Li YJ.,Guo Y.,...&王立成.(2017).Direct preparation of a graphene oxide modified monolith in a glass syringe as a solid-phase extraction cartridge for the extraction of quaternary ammonium alkaloids from Chinese patent medicine.Journal of Separation Science,40(22),4411-4419. |
MLA | Liang XJ,et al."Direct preparation of a graphene oxide modified monolith in a glass syringe as a solid-phase extraction cartridge for the extraction of quaternary ammonium alkaloids from Chinese patent medicine".Journal of Separation Science 40.22(2017):4411-4419. |
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