Selective Oxidative [4+2] Imine/Alkene Annulation with H2 Liberation Induced by Photo-Oxidation | |
Department | OSSO国家重点实验室 |
Hu, Xia1; Zhang, Guoting1; Bu, Faxiang1; Lei AW(雷爱文)1,2; Lei AW(雷爱文) | |
2018 | |
Source Publication | Angewandte Chemie International Edition |
ISSN | 1433-7851 |
Volume | 130Pages:1300-1304 |
Abstract | The oxidative [4+2] annulation reaction represents an elegant and versatile synthetic protocol for the construction of six‐membered heterocyclic compounds. Herein, a photoinduced oxidative [4+2] annulation of NH imines and alkenes was developed by utilizing a dual photoredox/cobaloxime catalytic system. Various multisubstituted 3,4‐dihydroisoquinolines can be obtained in good yields. This method is not only obviated the need of stiochiometric amounts of oxidants but also exhibited excellent atom economy by generating H2 as the only byproduct. Remarkably, high regioselectivity and trans diastereoselectivity can be achieved in this transformation even if the Z/E mixture of alkenes were employed. |
Keyword | Alkenes Annulations Cobalt Heterocycles Radicals |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1002/anie.201711359 |
Funding Organization | the National Natural Science Foundation of China (21390400;21520102003;21272180;21302148);the Hubei Province Natural Science Foundation of China (2013CFA081);the Research Fund for the Doctoral Program of Higher Education of China (20120141130002);the Ministry of Science and Technology of China (2012YQ120060);The Program of Introducing Talents of Discipline to Universities of China (111 Program) |
Indexed By | SCI |
Language | 英语 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/23779 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Lei AW(雷爱文) |
Affiliation | 1.Wuhan Univ, Inst Adv Studies, Coll Chem & Mol Sci, IAS, Wuhan 430072, Hubei, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China |
Recommended Citation GB/T 7714 | Hu, Xia,Zhang, Guoting,Bu, Faxiang,et al. Selective Oxidative [4+2] Imine/Alkene Annulation with H2 Liberation Induced by Photo-Oxidation[J]. Angewandte Chemie International Edition,2018,130:1300-1304. |
APA | Hu, Xia,Zhang, Guoting,Bu, Faxiang,Lei AW,&雷爱文.(2018).Selective Oxidative [4+2] Imine/Alkene Annulation with H2 Liberation Induced by Photo-Oxidation.Angewandte Chemie International Edition,130,1300-1304. |
MLA | Hu, Xia,et al."Selective Oxidative [4+2] Imine/Alkene Annulation with H2 Liberation Induced by Photo-Oxidation".Angewandte Chemie International Edition 130(2018):1300-1304. |
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