Palladium-catalyzed regiodivergent hydroaminocarbonylation of alkenes to primary amides with ammonium chloride | |
Department | OSSO国家重点实验室 |
Gao B(高宝)1; Zhang GY(张国营)1; Zhou, Xibing1; Huang HM(黄汉民)1,2; Huang HM(黄汉民) | |
2018 | |
Source Publication | Chemical Science |
ISSN | 2041-6520 |
Volume | 9Issue:2Pages:380-386 |
Abstract | Palladium-catalyzed hydroaminocarbonylation of alkenes for the synthesis of primary amides has long been an elusive aim. Here, we report an efficient catalytic system which enables inexpensive NH4Cl to be utilized as a practical alternative to gaseous ammonia for the palladium-catalyzed alkene-hydroaminocarbonylation reaction. Through appropriate choice of the palladium precursors and ligands, either branched or linear primary amides can be obtained in good yields with good to excellent regioselectivities. Primary mechanistic studies were conducted and disclosed that electrophilic acylpalladium species were capable of capturing the NH2-moiety from ammonium salts to form amides in the presence of CO with NMP as a base. |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1039/c7sc04054g |
Funding Organization | the National Natural Science Foundation of China (21672199;21702197);CAS Interdisciplinary Innovation Team, the Fundamental Research Funds for the Central Universities and the Anhui provincial Natural Science Foundation (1708085MB28) |
Indexed By | SCI |
Language | 英语 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/23769 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Huang HM(黄汉民) |
Affiliation | 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Dept Chem, Hefei 230026, Anhui, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China |
Recommended Citation GB/T 7714 | Gao B,Zhang GY,Zhou, Xibing,et al. Palladium-catalyzed regiodivergent hydroaminocarbonylation of alkenes to primary amides with ammonium chloride[J]. Chemical Science,2018,9(2):380-386. |
APA | Gao B,Zhang GY,Zhou, Xibing,Huang HM,&黄汉民.(2018).Palladium-catalyzed regiodivergent hydroaminocarbonylation of alkenes to primary amides with ammonium chloride.Chemical Science,9(2),380-386. |
MLA | Gao B,et al."Palladium-catalyzed regiodivergent hydroaminocarbonylation of alkenes to primary amides with ammonium chloride".Chemical Science 9.2(2018):380-386. |
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c7sc04054g.pdf(1098KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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