Facile synthesis of 1,4-diketones via three-component reactions of alpha-ketoaldehyde, 1,3-dicarbonyl compound, and a nucleophile in water | |
Department | OSSO国家重点实验室 |
Yang, Jian1; Mei, Fuming1; Fu, Shitao1; Gu YL(顾彦龙)1,2; Gu YL(顾彦龙) | |
2018 | |
Source Publication | Green Chemistry |
ISSN | 1463-9262 |
Volume | 20Issue:6Pages:1367-1374 |
Abstract | Three-component reactions of alkylglyoxals, 1,3-dicarbonyl compounds, and a nucleophile were performed under aqueous and catalyst-free conditions, which produced 1,4-diketone scaffolds in a straightforward way. Many compounds, such as indole, azaindole, pyrrole, 2-methylfuran, N,N-dimethylaniline, N-methylaniline, thiophenol, and benzyl mercaptan, were all able to act as nucleophiles to react with alkylglyoxal and 1,3-dicarbonyl compounds. The mechanim of this reaction was also investigated. The obtained 1,4-diketones can be easily converted to many valuable chemicals. |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1039/c7gc03644b |
Funding Organization | the National Natural Science Foundation of China (21761132014;21373093);the Fundamental Research Funds for the Central Universities of China (2016YXZD033) ;The Cooperative Innovation Center of Hubei Province;National Science and Technology Support Program (2105BAD21B05-1) |
Indexed By | SCI |
Language | 英语 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/23681 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Fu, Shitao; Gu YL(顾彦龙) |
Affiliation | 1.Huazhong Univ Sci & Technol, Key Lab Mat Chem Energy Convers & Storage, Hubei Key Lab Mat Chem & Serv Failure, Minist Educ,Sch Chem & Chem Engn, 1037 Luoyu Rd, Wuhan 430074, Peoples R China 2.Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Yang, Jian,Mei, Fuming,Fu, Shitao,et al. Facile synthesis of 1,4-diketones via three-component reactions of alpha-ketoaldehyde, 1,3-dicarbonyl compound, and a nucleophile in water[J]. Green Chemistry,2018,20(6):1367-1374. |
APA | Yang, Jian,Mei, Fuming,Fu, Shitao,Gu YL,&顾彦龙.(2018).Facile synthesis of 1,4-diketones via three-component reactions of alpha-ketoaldehyde, 1,3-dicarbonyl compound, and a nucleophile in water.Green Chemistry,20(6),1367-1374. |
MLA | Yang, Jian,et al."Facile synthesis of 1,4-diketones via three-component reactions of alpha-ketoaldehyde, 1,3-dicarbonyl compound, and a nucleophile in water".Green Chemistry 20.6(2018):1367-1374. |
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c7gc03644b.pdf(1879KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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