Mechanically Robust 3D Graphene-Hydroxyapatite Hybrid Bioscaffolds with Enhanced Osteoconductive and Biocompatible Performance | |
Department | 清洁能源化学与材料实验室 |
Xie, Weibo1,2,3; Song, Fuxiang4,5; Wang, Rui4; Sun, Shenglin4; Li, Miao4; Fan, Zengjie4; Liu, Bin4; Zhang, Qiangqiang2,3; Wang, Jizeng2,3 | |
2018 | |
Source Publication | Crystals |
ISSN | 2073-4352 |
Volume | 8Issue:2Pages:105(1-12) |
Abstract | In this paper, we describe three-dimensional (3D) hierarchical graphene–hydroxyapatite hybrid bioscaffolds (GHBs) with a calcium phosphate salt electrochemically deposited onto the framework of graphene foam (GF). The morphology of the hydroxyapatite (HA) coverage over GF was controlled by the deposition conditions, including temperature and voltage. The HA obtained at the higher temperature demonstrates the more uniformly distributed crystal grain with the smaller size. The as-prepared GHBs show a high elasticity with recoverable compressive strain up to 80%, and significantly enhanced strength with Young’s modulus up to 0.933 MPa compared with that of pure GF template (~7.5 kPa). Moreover, co-culture with MC3T3-E1 cells reveals that the GHBs can more effectively promote the proliferation of MC3T3-E1 osteoblasts with good biocompatibility than pure GF and the control group. The superior performance of GHBs suggests their promising applications as multifunctional materials for the repair and regeneration of bone defects. |
Keyword | Graphene-hydroxyapatite Hybrid Bioscaffolds Graphene Foam Electrochemical Deposition Mechanical Robustness Biocompatibility |
Subject Area | 材料科学与物理化学 |
DOI | 10.3390/cryst8020105 |
Funding Organization | the Natural Science Foundation of China (81571829;11472119;11421062;51702142);the Medical Subject Fund of Stomatology College of Lanzhou University (201502-3);the Fundamental Research Funds for the Central Universities (lzujbky-2015-293;lzujbky-2017-k17);the open project of State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (LSL-1505) |
Indexed By | SCI |
Language | 英语 |
compositor | 第五作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/23654 |
Collection | 清洁能源化学与材料实验室 |
Corresponding Author | Zhang, Qiangqiang; Wang, Jizeng |
Affiliation | 1.Lanzhou Univ, Hosp 2, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Coll Civil Engn & Mech, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, Key Lab Mech Disaster & Environm Western China, Minist Educ China, Lanzhou 730000, Peoples R China 4.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China 5.Chinese Acad Sci, Lab Clean Energy Chem & Mat, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Xie, Weibo,Song, Fuxiang,Wang, Rui,et al. Mechanically Robust 3D Graphene-Hydroxyapatite Hybrid Bioscaffolds with Enhanced Osteoconductive and Biocompatible Performance[J]. Crystals,2018,8(2):105(1-12). |
APA | Xie, Weibo.,Song, Fuxiang.,Wang, Rui.,Sun, Shenglin.,Li, Miao.,...&Wang, Jizeng.(2018).Mechanically Robust 3D Graphene-Hydroxyapatite Hybrid Bioscaffolds with Enhanced Osteoconductive and Biocompatible Performance.Crystals,8(2),105(1-12). |
MLA | Xie, Weibo,et al."Mechanically Robust 3D Graphene-Hydroxyapatite Hybrid Bioscaffolds with Enhanced Osteoconductive and Biocompatible Performance".Crystals 8.2(2018):105(1-12). |
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