Palladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles | |
Department | OSSO国家重点实验室 |
Li, Lixin1,4; Zhou, Xibing2; Yu, Bangkui2; Huang HM(黄汉民)1,2,3; Huang HM(黄汉民) | |
2017 | |
Source Publication | Organic Letters |
ISSN | 1523-7060 |
Volume | 19Issue:17Pages:4600-4603 |
Abstract | A novel palladium-catalyzed aminomethylamination of aminoalkenes with an aminal, functioning not only as an aminomethylation reagent but also as an oxidant, was developed. This direct and operationally simple protocol provides a fundamentally novel and unique approach toward the synthesis of 2-(2-aminoethyl)indoles and 2-(2-aminoethyl)pyrrolidines, which are important building blocks in synthetic organic chemistry. The unity of this method was highlighted by the rapid synthesis of Alosetron, a drug used for the treatment of irritable bowel syndrome. |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1021/acs.orglett.7b02203 |
Funding Organization | the CAS Interdisciplinary Innovation Team;the National Natural Science Foundation of China (21672199) |
Indexed By | SCI |
If | 6.579 |
Language | 英语 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/22459 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Huang HM(黄汉民) |
Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China 2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China 3.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
Recommended Citation GB/T 7714 | Li, Lixin,Zhou, Xibing,Yu, Bangkui,et al. Palladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles[J]. Organic Letters,2017,19(17):4600-4603. |
APA | Li, Lixin,Zhou, Xibing,Yu, Bangkui,Huang HM,&黄汉民.(2017).Palladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles.Organic Letters,19(17),4600-4603. |
MLA | Li, Lixin,et al."Palladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles".Organic Letters 19.17(2017):4600-4603. |
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