Graphene oxide/Ag nanoparticles cooperated with simvastatin as a high sensitive X-ray computed tomography imaging agent for diagnosis of renal dysfunctions | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Li Z(李湛)1; Longlong Tian2; Jianli Liu3; Wei Qi4; Qiang Wu3; Haijing Wang5; Mohammad Chand Ali,1; Wu WS(吴王锁)5; Qiu HD(邱洪灯)1; Qiu HD(邱洪灯) | |
2017 | |
Source Publication | Advanced Healthcare Materials |
ISSN | 2192-2640 |
Volume | 6Issue:18Pages:1700413(1-11) |
Abstract | Graphene oxides (GO) are attracting much attention in the diagnosis and therapy of the subcutaneous tumor as a novel biomaterial, but its diagnosis to tissue dysfunction is yet to be found. Here, a novel application of GO for diagnosis of renal dysfunction via contrast-enhanced computed tomography (CT) is proposed. In order to serve as contrast-enhanced agent, Ag nanoparticles (AgNPs) are composited on the surface of GO to promote its X-ray absorption, and then simvastatin is coinjected for eliminating in vivo toxicity induced by AgNPs. It is found that GO/AgNPs can enhance the imaging of CT into the lung, liver, and kidney of mice for a long circulation time (≈24 h) and a safety profile in vivo in the presence of simvastatin. Interestingly, the lower dose of GO/AgNPs (≈0.5 mg per kg bw) shows an excellent performance for CT imaging of renal perfusion, and visually exhibits the right renal dysfunction in model mice. Hence, this work suggests that graphene nanoparticles will play a vital role for the future medical translational development including drug carrier, biosensing, and disease therapy. |
Keyword | Ag Nanoparticles Ct Imaging Graphene Oxide Precise Diagnosis Simvastatin |
Subject Area | 分析化学与药物化学 |
DOI | 10.1002/adhm.201700413 |
Funding Organization | the National Natural Science Foundation of China (Grant Nos. 21405165;21675164;21650110454);the Funds for Distinguished Young Scientists of Gansu (Grant No. 1506RJDA281);the top priority program of “One-Three- Five” Strategic Planning of Lanzhou Institute of Chemical Physics, CAS |
Indexed By | SCI |
If | 5.110 |
Language | 英语 |
Funding Project | 药物分离材料研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/22227 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Qiu HD(邱洪灯) |
Affiliation | 1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000, China 2.School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Medical College of Soochow University Suzhou, Jiangsu 215123, China 3.Lanzhou University Second Hospital Lanzhou 730000, China 4.Institute of Applied Electromagnetic Engineering School of Electrical and Electronic Engineering Huazhong University of Science and Technology Wuhan 430000, China 5.Radiochemistry Laboratory Lanzhou University Lanzhou 730000, China |
Recommended Citation GB/T 7714 | Li Z,Longlong Tian,Jianli Liu,et al. Graphene oxide/Ag nanoparticles cooperated with simvastatin as a high sensitive X-ray computed tomography imaging agent for diagnosis of renal dysfunctions[J]. Advanced Healthcare Materials,2017,6(18):1700413(1-11). |
APA | Li Z.,Longlong Tian.,Jianli Liu.,Wei Qi.,Qiang Wu.,...&邱洪灯.(2017).Graphene oxide/Ag nanoparticles cooperated with simvastatin as a high sensitive X-ray computed tomography imaging agent for diagnosis of renal dysfunctions.Advanced Healthcare Materials,6(18),1700413(1-11). |
MLA | Li Z,et al."Graphene oxide/Ag nanoparticles cooperated with simvastatin as a high sensitive X-ray computed tomography imaging agent for diagnosis of renal dysfunctions".Advanced Healthcare Materials 6.18(2017):1700413(1-11). |
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2017-AHM-Li.pdf(11284KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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