| An NBD-based Fluorescent Turn-on Probe for the Detection of Homocysteine over Cysteine and Its Imaging Applications | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wang JM(王佳敏)1 ; Shao, Xiangmin2; Wang, Jianhong1; Shao SJ(邵士俊)3,4,5; Shao SJ(邵士俊)
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| 2017 | |
| Source Publication | Chemistry Letters
 |
| ISSN | 0366-7022 |
| Volume | 46Issue:4Pages:442-445 |
| Abstract | An NBD-based fluorescent probe (probe 1) for the detection of Hcy over Cys and GSH based on nucleophilic substitution and Smiles rearrangement reaction was designed and synthesized by the reaction of 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) with 1,4-dihydroxybenzene. The probe displayed many desired properties such as high specificity, appreciable solubility, and desirable response time. In addition, probe 1 has low cytotoxicity and detection of intracellular Hcy can be achieved by cell fluorescence imaging. |
| Keyword | Fluorescence Probe Bioimaging Thiol-containing Molecule |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1246/cl.161123 |
| Funding Organization | the National Natural Science Foundation of China (Nos. 21275150;21272056;21572239) |
| Indexed By | SCI |
| If | 1.801 |
| Language | 英语 |
| Funding Project | 药物分子识别研究组 |
| compositor | 第三作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/21732 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Wang, Jianhong; Shao SJ(邵士俊) |
| Affiliation | 1.Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Peoples R China 2.Zhengzhou Univ Ind Technol, Sch Pharm, Zhengzhou 451100, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem NW Plant Resources, Lanzhou 730000, Peoples R China 4.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 5.Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Wang JM,Shao, Xiangmin,Wang, Jianhong,et al. An NBD-based Fluorescent Turn-on Probe for the Detection of Homocysteine over Cysteine and Its Imaging Applications[J]. Chemistry Letters,2017,46(4):442-445. |
| APA | Wang JM,Shao, Xiangmin,Wang, Jianhong,Shao SJ,&邵士俊.(2017).An NBD-based Fluorescent Turn-on Probe for the Detection of Homocysteine over Cysteine and Its Imaging Applications.Chemistry Letters,46(4),442-445. |
| MLA | Wang JM,et al."An NBD-based Fluorescent Turn-on Probe for the Detection of Homocysteine over Cysteine and Its Imaging Applications".Chemistry Letters 46.4(2017):442-445. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| LZ01030021.pdf（1764KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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