Isolation and identification of antioxidant and alpha-glucosidase inhibitory compounds from fruit juice of Nitraria tangutorum | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Zhao, Jian-Qiang1; Wang YM(王衍明)2; Yang, Yan-Long3; Zeng, Ying3; Wang, Qi-Lan1; Shao, Yun1; Mei, Li-Juan1; Shi YP(师彦平)2; Tao, Yan-Duo1 | |
2017 | |
Source Publication | Food Chemistry |
ISSN | 0308-8146 |
Volume | 227Pages:93-101 |
Abstract | Nitraria tangutorum Bor., having edible berries, is valued for reputed health benefits in Qinghai-Tibet plateau. The phytochemical research on the fruit juice of N. tangutorum led to the isolation of twenty-six compounds including five new compounds, tangutorids A–D (1, 2, 3a, and 3b), and (3E,5E)-7-O-β-glucosyl-4-(2-methoxy-2-oxoethyl)hepta-3,5-dienoic acid (15). The structures of these compounds were elucidated through comprehensive spectroscopic analyses. Tangutorids A–F were the first examples of glucose-derived β-carbolines from natural products. The biogenetic pathways of 1–8 were proposed to involve Pictet–Spengler reactions and described starting from the co-isolated tryptophan (10) and corresponding aldehydes. All isolates were evaluated for their antioxidant and α-glucosidase inhibitory activities. Compounds 21, 22, and 24 showed antioxidant activity with SC50 values ranging from 12.2 ± 1.9 to 30.4 ± 2.7 μg/mL, and compound 1 showed strong α-glucosidase inhibitory effect with IC50 value of 63.3 ± 4.6 μg/mL. |
Keyword | Nitraria Tangutorum Glucose-derived Beta-carbolines Antioxidants Alpha-glucosidase Inhibitory |
Subject Area | 分析化学与药物化学 |
DOI | 10.1016/j.foodchem.2017.01.031 |
Funding Organization | the Significant Science and Technological Project of Qinghai Province (2014-GX-A3A);the Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Programme of Chinese Academy of Science (ZSTH-027) |
Indexed By | SCI |
If | 4.529 |
Language | 英语 |
Funding Project | 药物化学成分研究组 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21614 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Mei, Li-Juan; Tao, Yan-Duo |
Affiliation | 1.Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China 2.Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China 3.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China |
Recommended Citation GB/T 7714 | Zhao, Jian-Qiang,Wang YM,Yang, Yan-Long,et al. Isolation and identification of antioxidant and alpha-glucosidase inhibitory compounds from fruit juice of Nitraria tangutorum[J]. Food Chemistry,2017,227:93-101. |
APA | Zhao, Jian-Qiang.,Wang YM.,Yang, Yan-Long.,Zeng, Ying.,Wang, Qi-Lan.,...&Tao, Yan-Duo.(2017).Isolation and identification of antioxidant and alpha-glucosidase inhibitory compounds from fruit juice of Nitraria tangutorum.Food Chemistry,227,93-101. |
MLA | Zhao, Jian-Qiang,et al."Isolation and identification of antioxidant and alpha-glucosidase inhibitory compounds from fruit juice of Nitraria tangutorum".Food Chemistry 227(2017):93-101. |
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