| Sesquiterpenoids with Various Carbocyclic Skeletons from the Flowers of Chrysanthemum indicum | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Liu LL(刘磊磊)1; Thi Kim Quy Ha2; Ha W(哈伟)1 ; Won Keun Oh2; Yang JL(杨军丽)1; Shi YP(师彦平)1; Yang JL(杨军丽); Shi YP(师彦平)
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| 2017 | |
| Source Publication | Journal of Natural Products
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| ISSN | 0163-3864 |
| Volume | 80Issue:2Pages:298-307 |
| Abstract | A phytochemical investigation of the flowers of Chrysanthemum indicum yielded sesquiterpenoids 1–25 with various carbocyclic skeletons, including 10 new (1–10) and 15 known (11–25) analogues. The structures were elucidated via their physical data, while the absolute configuration of compounds 6, 8, and 10 was assessed via electronic circular dichroism analysis. The evaluation of the effect of sesquiterpenoids on porcine epidemic diarrhea virus (PEDV) replication showed that compounds 1–5, 12, 14, 16, 17, 19, and 21 increased cell viability against cell death in PEDV-injected cells. Compounds 2, 12, and 17 were selected and investigated for their inhibition of proteins required for PEDV replication. Compounds 2 and 17 significantly reduced PEDV nucleocapsid and spike protein synthesis compared with azauridin as a positive control. |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1021/acs.jnatprod.6b00694 |
| Funding Organization | the International Partnership Program of Chinese Academy of Sciences (No. 153631KYSB20160004);National Natural Science Foundation of China (No. 81673325);CAS Pioneer Hundred Talents Program;scientific research project of the Central Asia Drug Discovery and Development Centre of the Chinese Academy of Sciences (CAM 201404) |
| Indexed By | SCI |
| If | 3.281 |
| Language | 英语 |
| Funding Project | 药物化学成分研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/21476 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Yang JL(杨军丽); Shi YP(师彦平) |
| Affiliation | 1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People’s Republic of China 2.Korea Bioactive Natural Material Bank, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea |
| Recommended Citation GB/T 7714 | Liu LL,Thi Kim Quy Ha,Ha W,et al. Sesquiterpenoids with Various Carbocyclic Skeletons from the Flowers of Chrysanthemum indicum[J]. Journal of Natural Products,2017,80(2):298-307. |
| APA | Liu LL.,Thi Kim Quy Ha.,Ha W.,Won Keun Oh.,Yang JL.,...&师彦平.(2017).Sesquiterpenoids with Various Carbocyclic Skeletons from the Flowers of Chrysanthemum indicum.Journal of Natural Products,80(2),298-307. |
| MLA | Liu LL,et al."Sesquiterpenoids with Various Carbocyclic Skeletons from the Flowers of Chrysanthemum indicum".Journal of Natural Products 80.2(2017):298-307. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| acs.jnatprod.6b00694（3206KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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