Effect of Ionic Liquid on Separation and Purification of Tea Polyphenols Using Counter Current Chromatography | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Chen XF(陈小芬)1,2,3; Huang XY(黄新异)1,2; Wang GH(王高红)1,2,3; Zhang, Jia5; Di DL(邸多隆)1,2,4; Di DL(邸多隆) | |
2014 | |
Source Publication | Asian Journal of Chemistry |
ISSN | 0970-7077 |
Volume | 26Issue:8Pages:2271-2276 |
Abstract | In order to research the effect of ionic liquid as additives in two-phase solvent system on the behaviour of counter-current chromatography and develop more efficient methods of preparative separation and purification for natural products, a series of imidazolium-based ionic liquids with anion of [BF4]-(1-methyl-3-methylimidazolium tetrafluoroborate, 1-ethyl-3-methylimidazolium tetrafluoroborate, 1-propyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium tetrafluoroborate) and four structurally similar tea polyphenols ((-)-epigallocatechin-3-gallate, (-)-epicatechin, (-)-epicatechin-3-gallate, (-)-gallocatechin gallate) were, respectively chosen as additives and model molecules. The results showed that with the additive of 0.6 mol/L [MMIM][BF4] in ethyl acetate-water solvent system, the K values of (-)-epicatechin-3-gallate could drop from 30.46 to 3.47. The process of screening solvent systems based on ionic liquids was simpler and more efficiency than traditional ways. Subsequently, IR and NMR spectrum were performed to investigate the interactions between tea polyphenols and ionic liquids. It was considered that the major interaction between ionic liquid and target compounds was electrostatic attraction. |
Keyword | Counter Current Chromatography Ionic Liquids Tea Polyphenols |
Subject Area | 分析化学与药物化学 |
DOI | 10.14233/ajchem.2014.15695 |
Funding Organization | the Natural Sciences Foundation of China (NSFC No. 21175142);the "Hundred Talents Program" of the Chinese Academy of Sciences (CAS);West Light Foundation of the Chinese Academy of Sciences;Open Fund of Key Laboratory of Chemistry of Northwestern Plant Rescources of the Chinese Academy of Sciences (No. CNPR-2011kfkt-02) |
Indexed By | SCI |
Language | 英语 |
Funding Project | 药物工艺标准研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21308 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Di DL(邸多隆) |
Affiliation | 1.Chinese Acad Sci, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Resource Chem & New Mat, Qingdao 266100, Peoples R China 5.Gansu Coll Tradit Chinese Med, Dept Pharm, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Chen XF,Huang XY,Wang GH,et al. Effect of Ionic Liquid on Separation and Purification of Tea Polyphenols Using Counter Current Chromatography[J]. Asian Journal of Chemistry,2014,26(8):2271-2276. |
APA | Chen XF,Huang XY,Wang GH,Zhang, Jia,Di DL,&邸多隆.(2014).Effect of Ionic Liquid on Separation and Purification of Tea Polyphenols Using Counter Current Chromatography.Asian Journal of Chemistry,26(8),2271-2276. |
MLA | Chen XF,et al."Effect of Ionic Liquid on Separation and Purification of Tea Polyphenols Using Counter Current Chromatography".Asian Journal of Chemistry 26.8(2014):2271-2276. |
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