Synthesis of beta-Difluoroalkylated Acrylonitriles in the Presence of Copper Powder | |
Department | 固体润滑国家重点实验室 |
He, Yu-Tao1; Li, Lian-Hua1; Wang, Qiang1; Wu WS(吴王锁)2; Liang YM(梁永民)1,3; Liang YM(梁永民) | |
2016 | |
Source Publication | Organic Letters |
ISSN | 1523-7060 |
Volume | 18Issue:19Pages:5158-5161 |
Abstract | A highly regio- and stereoselective copper-mediated cyanodifluoroalkylation of alkynes with ethyl difluoroiodoacetate and trimethylsilyl cyanide (TMSCN) is described. The three-component coupling reaction provides straightforward access to a variety of useful difluoroalkyl-substituted acrylonitriles. The introduction of the nitrile unit is of great importance in drug discovery for the modification of this fragment. Preliminary mechanistic investigations indicate that a vinyl iodide intermediate and a difluoroalkyl radical might be involved in this transformation. |
Subject Area | 材料科学与物理化学 |
DOI | 10.1021/acs.orglett.6b02627 |
Funding Organization | the National Natural Science Foundation (NSF 21272101;21372074;21472073);the Fundamental Research Funds for the Central Universities (lzujbky-2014-243;lzujbky-2014-194);the "111" Project (J1103307);Program for Changjiang Scholars, and Innovative Research Team in University (IRT1138) |
Indexed By | SCI |
If | 6.579 |
Language | 英语 |
compositor | 第三作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21038 |
Collection | 固体润滑国家重点实验室(LSL) |
Corresponding Author | Liang YM(梁永民) |
Affiliation | 1.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Sch Nucl Sci & Technol, Radiochem Lab, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, State Key Lab Solid Lubricat, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | He, Yu-Tao,Li, Lian-Hua,Wang, Qiang,et al. Synthesis of beta-Difluoroalkylated Acrylonitriles in the Presence of Copper Powder[J]. Organic Letters,2016,18(19):5158-5161. |
APA | He, Yu-Tao,Li, Lian-Hua,Wang, Qiang,Wu WS,Liang YM,&梁永民.(2016).Synthesis of beta-Difluoroalkylated Acrylonitriles in the Presence of Copper Powder.Organic Letters,18(19),5158-5161. |
MLA | He, Yu-Tao,et al."Synthesis of beta-Difluoroalkylated Acrylonitriles in the Presence of Copper Powder".Organic Letters 18.19(2016):5158-5161. |
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