| Homogeneous silicone modified primary amine-Brønsted sted acid salt catalyzed aldol reaction: unexpected synergistic effect of polysiloxane with remarkable improvement of efficiency and stereoselectivity | |
| Department | 羰基合成与选择氧化国家重点实验室 |
| Xu LW(徐利文); Ju YD(鞠亚东); Li L(李莉); Qiu HY(邱化玉); Jiang JX(蒋剑雄); Lai GQ(来国桥) | |
| 2008 | |
| Source Publication | Tetrahedron Letters
 |
| ISSN | 0040-4039 |
| Volume | 49Pages:7037-7041 |
| Abstract | We have developed a new strategy to improve the stereoselectivity in enamine catalysis by the introduction of super-hydrophobic long-chain silicone/polysiloxane as support/functional group for a model aldol reaction. The homogeneous direct aldol reaction of cyclic ketones with different aromatic aldehydes catalyzed by polysiloxane-derived primary amines has been reported with high yields, good diastereoselectivity, and up to 99% ee. |
| Keyword | Enamine Catalysis Primary Amine Aldol Reaction Polysiloxane Organocatalysis |
| Subject Area | 物理化学 |
| Funding Organization | Hangzhou Normal University;the National Nature Science Foundation of China (Project No. 20572114) |
| Indexed By | SCI |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/1980 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Xu LW(徐利文); Lai GQ(来国桥) |
| Recommended Citation GB/T 7714 | Xu LW,Ju YD,Li L,et al. Homogeneous silicone modified primary amine-Brønsted sted acid salt catalyzed aldol reaction: unexpected synergistic effect of polysiloxane with remarkable improvement of efficiency and stereoselectivity[J]. Tetrahedron Letters,2008,49:7037-7041. |
| APA | 徐利文,鞠亚东,李莉,邱化玉,蒋剑雄,&来国桥.(2008).Homogeneous silicone modified primary amine-Brønsted sted acid salt catalyzed aldol reaction: unexpected synergistic effect of polysiloxane with remarkable improvement of efficiency and stereoselectivity.Tetrahedron Letters,49,7037-7041. |
| MLA | 徐利文,et al."Homogeneous silicone modified primary amine-Brønsted sted acid salt catalyzed aldol reaction: unexpected synergistic effect of polysiloxane with remarkable improvement of efficiency and stereoselectivity".Tetrahedron Letters 49(2008):7037-7041. |
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| 41_Tetrahedron Lett.（184KB） | 开放获取 | License | View Application Full Text | |||
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