Synergistic Acid-Catalyzed Synthesis of N-Aryl-Substituted Azacycles from Anilines and Cyclic Ethers | |
Department | OSSO国家重点实验室 |
Zhang ZB(张震北)1,2; Miao CX(苗成霞)1; Xia CG(夏春谷)1; Sun W(孙伟)1; Sun W(孙伟) | |
2016 | |
Source Publication | Organic Letters |
ISSN | 1523-7060 |
Volume | 18Issue:7Pages:1522-1525 |
Abstract | A metal-free and efficient approach to N-aryl-substituted azacycles from arylamines and cyclic ethers is described. In this synthesis, the synergistic effect between Lewis and Brønsted acids is crucial to the ring-opening of cyclic ethers and the subsequent cyclization. The use of B(C6F5)3 enabled the formation of frustrated Lewis pairs (FLPs) from the reactants, and the resulting FLPs allowed ready access to the N-arylazacycles in moderate to good yields via further cyclization. Water is the sole waste resulting from the reaction, thereby making it an environmentally benign process. |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1021/acs.orglett.6b00157 |
Funding Organization | the National Natural Science Foundation of China (Nos. 21473226;21133011) |
Indexed By | SCI |
If | 6.579 |
Language | 英语 |
Funding Project | 生物与仿生催化课题组;均相催化课题组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/19476 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Sun W(孙伟) |
Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
Recommended Citation GB/T 7714 | Zhang ZB,Miao CX,Xia CG,et al. Synergistic Acid-Catalyzed Synthesis of N-Aryl-Substituted Azacycles from Anilines and Cyclic Ethers[J]. Organic Letters,2016,18(7):1522-1525. |
APA | Zhang ZB,Miao CX,Xia CG,Sun W,&孙伟.(2016).Synergistic Acid-Catalyzed Synthesis of N-Aryl-Substituted Azacycles from Anilines and Cyclic Ethers.Organic Letters,18(7),1522-1525. |
MLA | Zhang ZB,et al."Synergistic Acid-Catalyzed Synthesis of N-Aryl-Substituted Azacycles from Anilines and Cyclic Ethers".Organic Letters 18.7(2016):1522-1525. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
acs.orglett.6b00157.(956KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment