Palladium-Catalyzed Formal Insertion of Carbenoids into Aminals via C-N Bond Activation | |
Department | OSSO国家重点实验室 |
Qin GP(秦贵平); Li LX(李立新); Li JW(李加文); Huang HM(黄汉民); Huang HM(黄汉民) | |
2015 | |
Source Publication | Journal of the American Chemical Society |
ISSN | 0002-7863 |
Volume | 137Issue:39Pages:12490-12493 |
Abstract | A new strategy for selective insertion of metal carbenes into C–N bond has been developed via Pd-catalyzed C–N bond activation. A series of aminals and α-diazoesters with different substituents were successfully incorporated even in 0.1 mol % of catalyst under mild conditions, affording a wide range of α,β-diamino acid esters with quarternary carbon-centers. Preliminary mechanistic studies uncovered that the unique electrophilic cyclopalladated species could easily react with diazoacetates to generate a Pd-carbenoid intermediate which was involved in the catalytic cycle. |
Subject Area | 材料科学与物理化学 |
DOI | 10.1021/jacs.5b08476 |
Funding Organization | the Chinese Academy of Sciences;the National Natural Science Foundation of China (21222203;21172226;21133011) |
Indexed By | SCI |
If | 12.113 |
Language | 英语 |
Funding Project | 有机功能材料研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/18645 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Huang HM(黄汉民) |
Affiliation | Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Qin GP,Li LX,Li JW,et al. Palladium-Catalyzed Formal Insertion of Carbenoids into Aminals via C-N Bond Activation[J]. Journal of the American Chemical Society,2015,137(39):12490-12493. |
APA | Qin GP,Li LX,Li JW,Huang HM,&黄汉民.(2015).Palladium-Catalyzed Formal Insertion of Carbenoids into Aminals via C-N Bond Activation.Journal of the American Chemical Society,137(39),12490-12493. |
MLA | Qin GP,et al."Palladium-Catalyzed Formal Insertion of Carbenoids into Aminals via C-N Bond Activation".Journal of the American Chemical Society 137.39(2015):12490-12493. |
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