Four-Component Synthesis of beta-Enaminone and Pyrazole through Phosphine-Free Palladium-Catalyzed Cascade Carbonylation | |
Department | OSSO国家重点实验室 |
Shi LJ(石利军); Xue LQ(薛立芹); Lang R(郎睿); Xia CG(夏春谷); Li FW(李福伟); Li FW(李福伟) | |
2014 | |
Source Publication | ChemCatChem |
ISSN | 1867-3880 |
Volume | 6Issue:9Pages:2560-2566 |
Abstract | The carbonylative domino synthesis of enaminones and pyrazoles has been performed with the N—N bidentate palladium catalyst to achieve excellent selectivity. These results have confirmed that the carbonylative Sonogashira coupling of iodobenzenes with terminal alkynes is accompanied by the Michael addition of amines or phenylhydrazine in a one-pot method, which generates the desired products. This protocol demonstrates wide substrate tolerance, including hitherto unused aromatic amines, to yield the corresponding pure aromatic b-enaminones, which are subsequently converted into the 3-acylindole derivatives under mild conditions. |
Keyword | Carbonylation Domino Reactions Heterocycles Homogeneous Catalysis Palladium |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1002/cctc.201402277 |
Funding Organization | the Chinese Academy of Sciences;the National Natural Science Foundation of China (21002106;21133011;21373246) |
Indexed By | SCI |
If | 4.556 |
Language | 英语 |
Funding Project | 均相催化课题组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/7053 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Li FW(李福伟) |
Affiliation | Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Shi LJ,Xue LQ,Lang R,et al. Four-Component Synthesis of beta-Enaminone and Pyrazole through Phosphine-Free Palladium-Catalyzed Cascade Carbonylation[J]. ChemCatChem,2014,6(9):2560-2566. |
APA | Shi LJ,Xue LQ,Lang R,Xia CG,Li FW,&李福伟.(2014).Four-Component Synthesis of beta-Enaminone and Pyrazole through Phosphine-Free Palladium-Catalyzed Cascade Carbonylation.ChemCatChem,6(9),2560-2566. |
MLA | Shi LJ,et al."Four-Component Synthesis of beta-Enaminone and Pyrazole through Phosphine-Free Palladium-Catalyzed Cascade Carbonylation".ChemCatChem 6.9(2014):2560-2566. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
石利军 ChemCatChem.pdf(466KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment