| A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing | |
| Department | 固体润滑国家重点实验室 |
Fan ZJ(范增杰)1; Liu B(刘斌)2; Wang JQ(王金清)1 ; Zhang SY(张松营)2; Lin QQ(林茜茜)2; Gong PW(公培伟)1; Ma LM(马立民)1; Yang SR(杨生荣)1; Wang JQ(王金清)
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| 2014 | |
| Source Publication | Advanced Functional Materials
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| ISSN | 1616-301X |
| Volume | 24Issue:25Pages:3933-3943 |
| Abstract | Avoiding wound infection and retaining an appropriate level of moisture around woundz are major challenges in wound care management. Therefore, designing hydrogels with desired antibacterial performance and good water-maintaining ability is of particular significance to promote the development of wound dressing. Thus a series of hydrogels are prepared by crosslinking of Ag/graphene composites with acrylic acid and N,N'-methylene bisacrylamide at different mass ratios. The antibacterial performance and accelerated wound-healing ability of hydrogel are systematically evaluated with the aim of attaining a novel and effective wound dressing. The as-prepared hydrogel with the optimal Ag to graphene mass ratio of 5:1 (Ag5G1) exhibits stronger antibacterial abilities than other hydrogels. Meanwhile, Ag5G1 hydrogel exhibits excellent biocompatibility, high swelling ratio, and good extensibility. More importantly, in vivo experiments indicate that Ag5G1 hydrogel can significantly accelerate the healing rate of artificial wounds in rats, and histological examination reveals that it helps to successfully reconstruct intact and thickened epidermis during 15 day of healing of impaired wounds. In one word, the present approach can shed new light on designing of antibacterial material like Ag/graphene composite hydrogel with promising applications in wound dressing. |
| Subject Area | 材料科学与物理化学 |
| DOI | 10.1002/adfm.201304202 |
| Funding Organization | the National Natural Science Foundation of China (Grant Nos. 51205385;51075384);“Top Hundred Talents Program” of Chinese Academy of Sciences |
| Indexed By | SCI |
| If | 11.805 |
| Language | 英语 |
| Funding Project | 聚合物摩擦学组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/6961 |
| Collection | 固体润滑国家重点实验室（LSL） |
| Corresponding Author | Wang JQ(王金清) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Fan ZJ,Liu B,Wang JQ,et al. A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing[J]. Advanced Functional Materials,2014,24(25):3933-3943. |
| APA | Fan ZJ.,Liu B.,Wang JQ.,Zhang SY.,Lin QQ.,...&王金清.(2014).A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing.Advanced Functional Materials,24(25),3933-3943. |
| MLA | Fan ZJ,et al."A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing".Advanced Functional Materials 24.25(2014):3933-3943. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 1 FZJ-AFM 2014.pdf（4996KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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