Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Sun JN(孙建楠)1,2![]() ![]() ![]() ![]() ![]() | |
2014 | |
Source Publication | Journal of Chromatography A
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ISSN | 0021-9673 |
Volume | 1352Pages:1-7 |
Abstract | An ionic liquid-based electromembrane extraction (IL-EME) method was presented, and its performance was compared with 2-ethylnitrobenzene (ENB) based EME for the determination of strychnine and brucine in human urine. For the two methods, the fundamental extraction parameters such as supported liquid membrane, voltage, extraction time, pH values of sample solution and acceptor solution, temperature and salting-out effect were separately optimized. IL-EME provided 96- and 122-fold enrichment factors for strychnine and brucine, respectively, which were better than those obtained in EME (83- and86-fold, respectively). The calibration curves were linear over the ranges of 20–720 µg L−1for strychnine and 20–640 µg L−1for brucine with the correlation coefficients higher than 0.9950. The repeatability of EME and IL-EME were evaluated by five parallel experiments giving the relative standard deviations of 5.12–6.98%. As the results indicated, compared with ENB based EME, the proposed IL-EME is more reliable and could provide better extraction performance for the determination of strychnine and brucine inhuman urine. |
Keyword | Ionic Liquid Electromembrane Extraction Strychnine Brucine Human Urine |
Subject Area | 分析化学与药物化学 |
DOI | 10.1016/j.chroma.2014.05.037 |
Funding Organization | the National Natural Science Foun-dation of China (Nos. 21105106;21375136);Natural Science Foundation of Gansu Province (No. 1107RJZA146) |
Indexed By | SCI |
If | 4.169 |
Language | 英语 |
Funding Project | 药物化学成分研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/6930 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Chen J(陈娟); Shi YP(师彦平) |
Affiliation | 1.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China 2.University of Chinese Academy of Sciences, Beijing 100039, People's Republic of China |
Recommended Citation GB/T 7714 | Sun JN,Chen J,Shi YP,et al. Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine[J]. Journal of Chromatography A,2014,1352:1-7. |
APA | Sun JN,Chen J,Shi YP,陈娟,&师彦平.(2014).Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine.Journal of Chromatography A,1352,1-7. |
MLA | Sun JN,et al."Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine".Journal of Chromatography A 1352(2014):1-7. |
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