Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine
Department中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
Sun JN(孙建楠)1,2; Chen J(陈娟)1; Shi YP(师彦平)1; Chen J(陈娟); Shi YP(师彦平)
2014
Source PublicationJournal of Chromatography A
ISSN0021-9673
Volume1352Pages:1-7
Abstract

An ionic liquid-based electromembrane extraction (IL-EME) method was presented, and its performance was compared with 2-ethylnitrobenzene (ENB) based EME for the determination of strychnine and brucine in human urine. For the two methods, the fundamental extraction parameters such as supported liquid membrane, voltage, extraction time, pH values of sample solution and acceptor solution, temperature and salting-out effect were separately optimized. IL-EME provided 96- and 122-fold enrichment factors for strychnine and brucine, respectively, which were better than those obtained in EME (83- and86-fold, respectively). The calibration curves were linear over the ranges of 20–720 µg L−1for strychnine and 20–640 µg L−1for brucine with the correlation coefficients higher than 0.9950. The repeatability of EME and IL-EME were evaluated by five parallel experiments giving the relative standard deviations of 5.12–6.98%. As the results indicated, compared with ENB based EME, the proposed IL-EME is more reliable and could provide better extraction performance for the determination of strychnine and brucine inhuman urine.

KeywordIonic Liquid Electromembrane Extraction Strychnine Brucine Human Urine
Subject Area分析化学与药物化学
DOI10.1016/j.chroma.2014.05.037
Funding Organizationthe National Natural Science Foun-dation of China (Nos. 21105106;21375136);Natural Science Foundation of Gansu Province (No. 1107RJZA146)
Indexed BySCI
If4.169
Language英语
Funding Project药物化学成分研究组
compositor第一作者单位
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Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.licp.cn/handle/362003/6930
Collection中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
Corresponding AuthorChen J(陈娟); Shi YP(师彦平)
Affiliation1.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China
2.University of Chinese Academy of Sciences, Beijing 100039, People's Republic of China
Recommended Citation
GB/T 7714
Sun JN,Chen J,Shi YP,et al. Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine[J]. Journal of Chromatography A,2014,1352:1-7.
APA Sun JN,Chen J,Shi YP,陈娟,&师彦平.(2014).Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine.Journal of Chromatography A,1352,1-7.
MLA Sun JN,et al."Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine".Journal of Chromatography A 1352(2014):1-7.
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