| Supramolecular Hybrid Hydrogel Based on Host-Guest Interaction and Its Application in Drug Delivery | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Yu J(于京)1,2,3 ; Ha W(哈伟)1,2; Sun JN(孙建楠)1,2; Shi YP(师彦平)1,2; Shi YP(师彦平)
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| 2014 | |
| Source Publication | ACS Applied Materials & Interfaces
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| ISSN | 1944-8244 |
| Volume | 6Issue:22Pages:19544-19551 |
| Abstract | In this work, we developed a simple, novel method for constructing gold nanocomposite supramolecular hybrid hydrogels for drug delivery, in which gold nanocrystals were utilized as building blocks. First, methoxypoly(ethylene glycol) thiol (mPEG-SH, molecular weight (MW) = 5 K) capped gold nanocrystals (nanospheres and nanorods) were prepared via a facile one-step ligand-exchange procedure. Then, the homogeneous supramolecular hybrid hydrogels were formed, after adding α-cyclodextrin (α-CD) into PEG-modified gold nanocrystal solutions, due to the host–guest inclusion. Both gold nanoparticles and inclusion complexes formed between α-CD and PEG chain provided the supra-cross-links, which are beneficial to the gelation formation. The resulting hybrid hydrogels were fully characterized by a combination of techniques including X-ray diffraction, rheology studies, and scanning electron microscopy. Meanwhile, the hybrid hydrogel systems demonstrated unique reversible gel–sol transition properties at a certain temperature caused by the temperature-responsive reversible supramolecular assembly. The drug delivery applications of such hybrid hydrogels were further investigated in which doxorubicin was selected as a model drug for in vitro release, cytotoxicity, and intracellular release studies. We believe that the development of such hybrid hydrogels will provide new and therapeutically useful means for medical applications. |
| Keyword | Supramolecular Hybrid Hydrogel Host-guest Inclusion Gold Nanoparticles Rug Delivery |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1021/am505649q |
| Funding Organization | the National Nature Science Foundation of China (Nos. 21105106;21375136) |
| Indexed By | SCI |
| If | 6.723 |
| Language | 英语 |
| Funding Project | 药物化学成分研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/6929 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Shi YP(师彦平) |
| Affiliation | 1.Chinese Acad Sci, Key Lab Chem Northwestern Plant Resources CAS, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Nat Med Gansu Prov, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Yu J,Ha W,Sun JN,et al. Supramolecular Hybrid Hydrogel Based on Host-Guest Interaction and Its Application in Drug Delivery[J]. ACS Applied Materials & Interfaces,2014,6(22):19544-19551. |
| APA | Yu J,Ha W,Sun JN,Shi YP,&师彦平.(2014).Supramolecular Hybrid Hydrogel Based on Host-Guest Interaction and Its Application in Drug Delivery.ACS Applied Materials & Interfaces,6(22),19544-19551. |
| MLA | Yu J,et al."Supramolecular Hybrid Hydrogel Based on Host-Guest Interaction and Its Application in Drug Delivery".ACS Applied Materials & Interfaces 6.22(2014):19544-19551. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| ACSami-2014(YuJ).pdf（8821KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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