Tunable Temperature-Responsive Supramolecular Hydrogels Formed by Prodrugs As a Codelivery System | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Ha W(哈伟); Yu J(于京); Song XY(宋昕玥); Chen J(陈娟); Shi YP(师彦平); Shi YP(师彦平) | |
2014 | |
Source Publication | ACS Applied Materials & Interfaces |
ISSN | 1944-8244 |
Volume | 6Issue:13Pages:10623-10630 |
Abstract | Taking advantage of the strong hydrophobicity of the anticancer drug camptothecin (CPT), the CPT molecule was conjugated to a class of low-molecular-weight (MW) poly(ethylene glycol) (PEG) chains (MW = 500, 1000, and 2000), forming an amphiphilic prodrug. The CPT-PEG prodrug formed stable hydrogels based on a combination of the partial inclusion complexation between one end of the PEG blocks and α-CD and the hydrophobic aggregation of CPT groups. Meanwhile, the formed hydrogels could be loaded with water-soluble drug 5-fluorouracil (5-FU), which is always combined with CPT drugs to enhance their anticancer activity. Moreover, the hydrogel systems demonstrate unique structure-related reversible gel−sol transition properties at a certain temperature due to the reversible supramolecular assembly, and the gel−sol transition temperature could be modulated by varying the length of the PEG chain and the concentrations of α-CD, demonstrating the possibility of achieving on-demand gel−sol transitions. The structure-related reversible gel−sol transition properties were proved by rheological property, XRD, DSC, and SEM measurements. The different controlled release profiles of two different anticancer drugs showed significant temperature-dependent properties. This easily prepared supramolecular hydrogel with excellent biocompatibility and tunable temperature responsiveness has significant potential for controlled drug release applications. |
Keyword | Temperature-sensitive Hydrogels Tunable Host-guest Inclusion Drug Combination Codelivery System |
Subject Area | 分析化学与药物化学 |
DOI | 10.1021/am5022864 |
Funding Organization | the National Nature Science Foundation of China (Nos. 21105106;21375136). |
Indexed By | SCI |
If | 6.723 |
Language | 英语 |
Funding Project | 药物化学成分研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/6921 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Shi YP(师彦平) |
Affiliation | Key Laboratory of Chemistry of Northwestern Plant Resources of the CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China |
Recommended Citation GB/T 7714 | Ha W,Yu J,Song XY,et al. Tunable Temperature-Responsive Supramolecular Hydrogels Formed by Prodrugs As a Codelivery System[J]. ACS Applied Materials & Interfaces,2014,6(13):10623-10630. |
APA | Ha W,Yu J,Song XY,Chen J,Shi YP,&师彦平.(2014).Tunable Temperature-Responsive Supramolecular Hydrogels Formed by Prodrugs As a Codelivery System.ACS Applied Materials & Interfaces,6(13),10623-10630. |
MLA | Ha W,et al."Tunable Temperature-Responsive Supramolecular Hydrogels Formed by Prodrugs As a Codelivery System".ACS Applied Materials & Interfaces 6.13(2014):10623-10630. |
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ACSami-2014(HaW).pdf(6841KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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