| Adsorption and release of ofloxacin from acid- and heat-treated halloysite; Adsorption and release of ofloxacin from acid- and heat-treated halloysite | |
| Department | 环境材料与生态化学研究发展中心 ; 环境材料与生态化学研究发展中心 |
Wang Q(汪琴)1 ; Zhang JP(张俊平)1; Zheng Y(郑玥)2; Wang AQ(王爱勤)1; Zhang JP(张俊平)
| |
| 2014 ; 2014 | |
| Source Publication | Colloids and Surfaces B: Biointerfaces
 ; Colloids and Surfaces B: Biointerfaces
|
| ISSN | 0927-7765 ; 0927-7765 |
| Volume | 113Issue:1Pages:51-58 |
| Abstract | Halloysite nanotube is an ideal vehicle of the controlled release of drugs. In this study, we systematicallyinvestigated the effects of acid- and heat-treatments on the physicochemical properties, structure andmorphology of halloysite by XRD, FTIR, SEM and TEM. Afterwards, the adsorption and in vitro release properties of halloysite for cationic ofloxacin (OFL) were evaluated. The results indicate that HCl treatment has no influence on the crystal structure of halloysite, whereas it becomes amorphous after calcined at temperature higher than 500 ℃. Both acid- and heat-treatments have no evident influence on the tubularstructure of halloysite. OFL was adsorbed onto halloysite via electrostatic interaction between protonated OFL and negative halloysite surface, cation exchange as well as electrostatic interaction between the OFL-Al3+complexes and the negative halloysite surface. Acid-treatment facilitates the release of the adsorbed OFL compared with the natural halloysite in spite of a slight decrease of adsorption capacity. However, heat-treatment results in a sharp decrease of adsorption capacity for OFL owning to the OFL-promoted dissolution of aluminum and the disappearance of the porous structure. Although heat-treatment also facilitates release of the adsorbed OFL, the amount of OFL released is in fact less than the natural halloysite owing to the very low adsorption capacity. Thus, acid-activation is an effective protocol to improve the adsorption and release of halloysite for cationic drug molecules.; Halloysite nanotube is an ideal vehicle of the controlled release of drugs. In this study, we systematicallyinvestigated the effects of acid- and heat-treatments on the physicochemical properties, structure andmorphology of halloysite by XRD, FTIR, SEM and TEM. Afterwards, the adsorption and in vitro release properties of halloysite for cationic ofloxacin (OFL) were evaluated. The results indicate that HCl treatment has no influence on the crystal structure of halloysite, whereas it becomes amorphous after calcined at temperature higher than 500 ℃. Both acid- and heat-treatments have no evident influence on the tubularstructure of halloysite. OFL was adsorbed onto halloysite via electrostatic interaction between protonated OFL and negative halloysite surface, cation exchange as well as electrostatic interaction between the OFL-Al3+complexes and the negative halloysite surface. Acid-treatment facilitates the release of the adsorbed OFL compared with the natural halloysite in spite of a slight decrease of adsorption capacity. However, heat-treatment results in a sharp decrease of adsorption capacity for OFL owning to the OFL-promoted dissolution of aluminum and the disappearance of the porous structure. Although heat-treatment also facilitates release of the adsorbed OFL, the amount of OFL released is in fact less than the natural halloysite owing to the very low adsorption capacity. Thus, acid-activation is an effective protocol to improve the adsorption and release of halloysite for cationic drug molecules. |
| Keyword | Halloysite Halloysite Acid-treatment Acid-treatment Heat-treatment Heat-treatment Adsorption And Release Adsorption And Release Ofloxacin Ofloxacin |
| Subject Area | 环境材料与生态化学 ; 环境材料与生态化学 |
| DOI | 10.1016/j.colsurfb.2013.08.036 ; 10.1016/j.colsurfb.2013.08.036 |
| Funding Organization | the “National Natural Science Foundation of China” (No. 51003112);the “Special Research Fund of Scholarship of Dean of CAS”;the “Hundred Talents Program of the Chinese Academy of Sciences” ; the “National Natural Science Foundation of China” (No. 51003112);the “Special Research Fund of Scholarship of Dean of CAS”;the “Hundred Talents Program of the Chinese Academy of Sciences” |
| Indexed By | SCI ; SCI |
| If | 4.152 ; 4.152 |
| Language | 英语 ; 英语 |
| Funding Project | 功能复合材料组 ; 功能复合材料组 |
| compositor | 第一作者单位 ; 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/6866 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | Zhang JP(张俊平) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China 2.Nanjing Univ Chinese Med, Grad Univ, Nanjing 210046, Jiangsu, Peoples R China |
| Recommended Citation GB/T 7714 | Wang Q,Zhang JP,Zheng Y,et al. Adsorption and release of ofloxacin from acid- and heat-treated halloysite, Adsorption and release of ofloxacin from acid- and heat-treated halloysite[J]. Colloids and Surfaces B: Biointerfaces, Colloids and Surfaces B: Biointerfaces,2014, 2014,113, 113(1):51-58, 51-58. |
| APA | Wang Q,Zhang JP,Zheng Y,Wang AQ,&张俊平.(2014).Adsorption and release of ofloxacin from acid- and heat-treated halloysite.Colloids and Surfaces B: Biointerfaces,113(1),51-58. |
| MLA | Wang Q,et al."Adsorption and release of ofloxacin from acid- and heat-treated halloysite".Colloids and Surfaces B: Biointerfaces 113.1(2014):51-58. |
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| Acid- and heat-activ（1619KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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