| Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment | |
| Department | 固体润滑国家重点实验室 |
Liu GQ(刘国强)1,2 ; Liu ZL(刘志鲁)1; Li N(李娜)3; Wang XL(王晓龙)1; Zhou F(周峰)1; Liu WM(刘维民)1; Wang XL(王晓龙); Zhou F(周峰)
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| 2014 | |
| Source Publication | ACS Applied Materials and Interfaces
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| ISSN | 1944-8244 |
| Volume | 6Issue:22Pages:20452-20463 |
| Abstract | We report the fabrication of poly(3-sulfopropyl methacrylate potassium salt) (PSPMK) brushes grafted poly(N-isopropylacrylamide) (PNIPAAm) microgels and their potential as artificial synovial fluid for biomimetic aqueous lubrication and arthritis treatment. The negatively charged PSPMK brushes and thermosensitive PNIPAAm microgels play water-based hydration lubrication and temperature-triggered drug release, respectively. Under soft friction pairs, an ultralow coefficient of friction was achieved, while the hairy thermosensitive microgels showed a desirable temperature-triggered drugs release performance. Such a soft charged hairy microgel offers great possibility for designing intelligent synovial fluid. What is more, the combination of lubrication and drug loading capabilities enables the large clinical potential of novel soft hairy nanoparticles as synthetic joint lubricant fluid in arthritis treatment. |
| Keyword | Hairy Microgels Polyelectrolyte Brushes Hydration Lubrication Biomimetic Synovial Fluid Arthritis Treatment |
| Subject Area | 材料科学与物理化学 |
| DOI | 10.1021/am506026e |
| Funding Organization | NSFC (21125316;21303233;51335010;21434009);973 projects (2013CB632300);Key Research Program of CAS (KJZD-EW-M01) |
| Indexed By | SCI |
| If | 6.723 |
| Language | 英语 |
| Funding Project | 材料表面与界面行为研究组;空间润滑材料组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/6843 |
| Collection | 固体润滑国家重点实验室（LSL） |
| Corresponding Author | Wang XL(王晓龙); Zhou F(周峰) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Liu GQ,Liu ZL,Li N,et al. Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment[J]. ACS Applied Materials and Interfaces,2014,6(22):20452-20463. |
| APA | Liu GQ.,Liu ZL.,Li N.,Wang XL.,Zhou F.,...&周峰.(2014).Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment.ACS Applied Materials and Interfaces,6(22),20452-20463. |
| MLA | Liu GQ,et al."Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment".ACS Applied Materials and Interfaces 6.22(2014):20452-20463. |
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| ACS Appl. Mater. Int（6973KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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