Heterogeneously copper-catalyzed oxidative synthesis of imidazo[1,2-a]pyridines using 2-aminopyridines and ketones under ligand- and additive-free conditions | |
Department | ERC国家工程研究中心 |
Meng X(孟旭); Wang YM(王艳敏); Yu CY(于超英); Zhao PQ(赵培庆); Zhao PQ(赵培庆) | |
The second department | osso国家重点实验室 |
2014 | |
Source Publication | RSC Advances |
ISSN | 2046-2069 |
Volume | 4Issue:52Pages:27301-27307 |
Abstract | An efficient and mild heterogeneously CuCl2/nano-TiO2-catalyzed aerobic synthesis of imidazo[1,2-a] pyridines from 2-aminopyridines and ketones has been developed using air as the oxidant in the absence of any ligands and additives. This strategy was compatible with a large range of substrates, including unactivated aryl ketones and unsaturated ketones and went through the C–H bond functionalization mechanism instead of I--assisted Ortoleva-King reaction to provide the corresponding imidazo[1,2-a] pyridines in good yields with low catalyst loading (0.8 mol%). Moreover, the heterogeneous catalyst can be successfully employed in gram-scale synthesis and reused many times without the significant loss of catalytic activity. |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1039/c4ra03299c |
Indexed By | SCI |
If | 3.840 |
Language | 英语 |
Funding Project | 催化新工艺研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/5885 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) 精细石油化工中间体国家工程研究中心(ERC) |
Corresponding Author | Zhao PQ(赵培庆) |
Affiliation | Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Meng X,Wang YM,Yu CY,et al. Heterogeneously copper-catalyzed oxidative synthesis of imidazo[1,2-a]pyridines using 2-aminopyridines and ketones under ligand- and additive-free conditions[J]. RSC Advances,2014,4(52):27301-27307. |
APA | Meng X,Wang YM,Yu CY,Zhao PQ,&赵培庆.(2014).Heterogeneously copper-catalyzed oxidative synthesis of imidazo[1,2-a]pyridines using 2-aminopyridines and ketones under ligand- and additive-free conditions.RSC Advances,4(52),27301-27307. |
MLA | Meng X,et al."Heterogeneously copper-catalyzed oxidative synthesis of imidazo[1,2-a]pyridines using 2-aminopyridines and ketones under ligand- and additive-free conditions".RSC Advances 4.52(2014):27301-27307. |
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