| Highly Enantioselective Addition of Terminal Alkynes to Aldehydes Catalyzed by a New Chiral beta-Sulfonamide Alcohol/Ti((OPr)-Pr-i)(4)/Et2Zn/R3N Catalyst System | |
| Department | 羰基合成与选择氧化国家重点实验室 |
| Qiu L(邱立); Wang Q(王全); Lin L(林利); Liu XD(刘晓东); Jiang XX(蒋先兴); Zhao QY(赵庆阳); Hu GW(胡国文); Wang R(王锐) | |
| 2009 | |
| Source Publication | Chirality
 |
| ISSN | 0899-0042 |
| Volume | 21Pages:316-323 |
| Abstract | A new catalytic system, generated from the readily available and inexpensive b-sulfonamide alcohol L*, Ti(OiPr)4, Et2Zn, and tertiary amine base (R3N), effectively catalyzes the enantioselective addition of various terminal alkynes including some quite challenging alkynes to aldehydes in good yields and excellent enantioselectivities. Up to 96% yield and >99% enantioselectivity were achieved with the use of N,Ndiisoproylethylamine (DIPEA) as an additive in this asymmetric addition. |
| Keyword | Enantioselective Addition Sulfonamide Alcohol Tertiary Amine Base Terminal Alkynes Aldehydes |
| Subject Area | 物理化学 |
| Funding Organization | Natural Science Foundation of China (Contract grant numbers: 20525206;20772052;20621091);Ministry of Education of China (Chang Jiang Program) |
| Indexed By | SCI |
| Language | 英语 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/572 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Wang R(王锐) |
| Recommended Citation GB/T 7714 | Qiu L,Wang Q,Lin L,et al. Highly Enantioselective Addition of Terminal Alkynes to Aldehydes Catalyzed by a New Chiral beta-Sulfonamide Alcohol/Ti((OPr)-Pr-i)(4)/Et2Zn/R3N Catalyst System[J]. Chirality,2009,21:316-323. |
| APA | 邱立.,王全.,林利.,刘晓东.,蒋先兴.,...&王锐.(2009).Highly Enantioselective Addition of Terminal Alkynes to Aldehydes Catalyzed by a New Chiral beta-Sulfonamide Alcohol/Ti((OPr)-Pr-i)(4)/Et2Zn/R3N Catalyst System.Chirality,21,316-323. |
| MLA | 邱立,et al."Highly Enantioselective Addition of Terminal Alkynes to Aldehydes Catalyzed by a New Chiral beta-Sulfonamide Alcohol/Ti((OPr)-Pr-i)(4)/Et2Zn/R3N Catalyst System".Chirality 21(2009):316-323. |
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| B23_Chirality,2009,2（124KB） | 开放获取 | License | View Application Full Text | |||
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