| Palladium-Catalyzed sp(2) and sp(3) C-H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles | |
| Department | OSSO国家重点实验室 |
| Wang GW(王刚伟)1; Zhou AX(周安西)1; Wang JJ(王君姣)1; Hu RB(胡荣斌)1; Yang SD(杨尚东)1,2; Yang SD(杨尚东) | |
| 2013 | |
| Source Publication | Organic Letters
 |
| ISSN | 1523-7060 |
| Volume | 15Issue:20Pages:5270-5273 |
| Abstract | The first Pd(II)-catalyzed C-H addition to isatins by direct sp2/sp3 C-H bond activation for the construction of 3-substituted-3-hydroxy-2-oxindoles is reported. The bidentate nitrogen ligands were found to promote this reaction. Specifically, the preliminary bioassay indicated that 3-(5-chlorobenzoxazole)-3-hydroxy-N-benzyl-2-oxindole (2w) is a new inhibitor of human kidney cancer and hepatocellular carcinoma cells. Moreover, this reaction system exhibits great functional group tolerance and requires no directing group, extra base, or additives. |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1021/oI402494e |
| Funding Organization | the NSFC (Nos. 21072079;21272100);Program for New Century Excellent Talents in University (NCET-11-0215) |
| Indexed By | SCI |
| If | 6.324 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4953 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Yang SD(杨尚东) |
| Affiliation | 1.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Wang GW,Zhou AX,Wang JJ,et al. Palladium-Catalyzed sp(2) and sp(3) C-H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles[J]. Organic Letters,2013,15(20):5270-5273. |
| APA | Wang GW,Zhou AX,Wang JJ,Hu RB,Yang SD,&杨尚东.(2013).Palladium-Catalyzed sp(2) and sp(3) C-H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles.Organic Letters,15(20),5270-5273. |
| MLA | Wang GW,et al."Palladium-Catalyzed sp(2) and sp(3) C-H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles".Organic Letters 15.20(2013):5270-5273. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Org. Lett., 2013, 15（349KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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