| Sc(OTf)(3)-Catalyzed Dehydrogenative Cyclization for Synthesis of N-Methylacridones | |
| Department | OSSO国家重点实验室 |
| Li XA(李喜安)1; Wang HL(王红利)1; Yang SD(杨尚东)1,2; Yang SD(杨尚东) | |
| 2013 | |
| Source Publication | Organic Letters
 |
| ISSN | 1523-7060 |
| Volume | 15Issue:8Pages:1794-1797 |
| Abstract | A novel method has been developed for the synthesis of substituted N-methylacridones from 2-(N-methyl-N-phenylamino)benzaldehydes via dehydrogenative cyclization. This transformation involves two primary processes: the aldehyde first coordinates with Sc(OTf)3 and induces the aromatic electrophilic substitution (SEAr) reaction to formthe active intermediate N-methyl-acridin-9-ol,which is then quickly oxidized in situ to afford the acridones. Furthermore, the procedure involved is both environmental friendly and atom efficient; H2O is the only byproduct in this reaction. |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1021/ol400371h |
| Funding Organization | the NSFC (Nos. 21072079;21272100);Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT: IRT1138) |
| Indexed By | SCI |
| If | 6.324 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4950 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Yang SD(杨尚东) |
| Affiliation | 1.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Li XA,Wang HL,Yang SD,et al. Sc(OTf)(3)-Catalyzed Dehydrogenative Cyclization for Synthesis of N-Methylacridones[J]. Organic Letters,2013,15(8):1794-1797. |
| APA | Li XA,Wang HL,Yang SD,&杨尚东.(2013).Sc(OTf)(3)-Catalyzed Dehydrogenative Cyclization for Synthesis of N-Methylacridones.Organic Letters,15(8),1794-1797. |
| MLA | Li XA,et al."Sc(OTf)(3)-Catalyzed Dehydrogenative Cyclization for Synthesis of N-Methylacridones".Organic Letters 15.8(2013):1794-1797. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Org. Lett., 2013, 15（280KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment