| Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wei JT(魏鉴腾)1,2,3 ; Wang SJ(王淑娟)4; Liu G(刘格)5; Pei D(裴栋)1,2,3; Liu YF(刘永峰)1,2,3; Liu Y(刘毅)1,2,3; Di DL(邸多隆)1,2,3; Di DL(邸多隆)
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| 2014 | |
| Source Publication | International Journal of Biological Macromolecules
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| ISSN | 0141-8130 |
| Volume | 64Pages:1-5 |
| Abstract | The effects of polysaccharides from Enteromorpha prolifera (PEP) on cell-mediated immunity, humoral immunity and mononuclear phagocytic system function were evaluated to assess the immunomodulatory potential of these macromolecules. Relevant immunological mechanisms were verified by biochemical assays and western blot analysis. Results showed that PEP could induce splenocyte proliferation. In vivo experiments on Kunming mice confirmed that PEP could improve cell-mediated immunity, humoral immunity and mononuclear phagocytic system function. To illustrate the mechanism, we determined several immune-related enzymes in the thymus and spleen. The results indicated that PEP could enhance the activities of alkaline phosphatase, superoxide dismutase and lactate dehydrogenase. PEP could also increase the level of NF-kB. These results suggested that PEP exhibited potent immunomodulatory properties and could be used as a novel potential immunostimulant in food and pharmaceutical industries. |
| Keyword | Enteromoipha Prolifera Polysaccharide Immune Response Immune-related Enzyme Nf-kb |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.ijbiomac.2013.11.013 |
| Funding Organization | the National Natural Sciences Foundation of China (20974116;21175142) |
| Indexed By | SCI |
| If | 2.858 |
| Language | 英语 |
| Funding Project | 药物工艺标准研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4905 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Di DL(邸多隆) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Ctr Resource Chem & New Mat, Qingdao 266100, Peoples R China 4.Mariculture Inst Shandong Prov, Qingdao 266002, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| Recommended Citation GB/T 7714 | Wei JT,Wang SJ,Liu G,et al. Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice[J]. International Journal of Biological Macromolecules,2014,64:1-5. |
| APA | Wei JT.,Wang SJ.,Liu G.,Pei D.,Liu YF.,...&邸多隆.(2014).Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice.International Journal of Biological Macromolecules,64,1-5. |
| MLA | Wei JT,et al."Polysaccharides from Enteromorpha prolifera enhance the immunity of normal mice".International Journal of Biological Macromolecules 64(2014):1-5. |
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| File Name/Size | DocType | Version | Access | License | ||
| Polysaccharides from（731KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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