| Direct Asymmetric Michael Addition of Thioether-based Aryl Sulfanyl-propan-2-one to Nitroalkenes Catalyzed by a Chiral Amine-Thiourea Bifunctional Organocatalyst | |
| Department | 羰基合成与选择氧化国家重点实验室 |
| Jiang XX(蒋先兴); Zhang BZ(张邦治); Zhang YF(张义福); Lin L(林利); Yan WJ(阎文锦); Wang R(王锐) | |
| 2010 | |
| Source Publication | Chirality
 |
| ISSN | 1520-636X |
| Volume | 22Pages:625-634 |
| Abstract | Although the organocatalytic direct asymmetric Michael reactions of carbonyl compounds to nitroalkenes have been investigated intensely, the Michael reaction of the thioether-based donors remains a rather undeveloped field. This work concerns the asymmetric Michael addition of aryl sulfanyl-propan-2-one to nitroalkenes with benzoic acid as an additive, and chiral amine-thiourea as a bifunctional organocatalyst. The reactions provided the highly functionalized chiral adducts with excellent enantioselectivities (up to 96% ee) and good yields. Moreover, the further transformed products exhibited excellent diastereoselectivity. |
| Keyword | Asymmetric Michael Addition Aryl Sulfanyl-propan-2-one Nitroalkenes Thiourea Bifunctional Organocatalyst |
| Subject Area | 物理化学 |
| Funding Organization | Natural Science Foundation of China (Contract grant numbers: 20525206;20772052;20621091);Chang Jiang Program of the Ministry of Education of China |
| Indexed By | SCI |
| Language | 英语 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/486 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Wang R(王锐) |
| Recommended Citation GB/T 7714 | Jiang XX,Zhang BZ,Zhang YF,et al. Direct Asymmetric Michael Addition of Thioether-based Aryl Sulfanyl-propan-2-one to Nitroalkenes Catalyzed by a Chiral Amine-Thiourea Bifunctional Organocatalyst[J]. Chirality,2010,22:625-634. |
| APA | 蒋先兴,张邦治,张义福,林利,阎文锦,&王锐.(2010).Direct Asymmetric Michael Addition of Thioether-based Aryl Sulfanyl-propan-2-one to Nitroalkenes Catalyzed by a Chiral Amine-Thiourea Bifunctional Organocatalyst.Chirality,22,625-634. |
| MLA | 蒋先兴,et al."Direct Asymmetric Michael Addition of Thioether-based Aryl Sulfanyl-propan-2-one to Nitroalkenes Catalyzed by a Chiral Amine-Thiourea Bifunctional Organocatalyst".Chirality 22(2010):625-634. |
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