| Cooperative Catalysis with Aldehydes and Copper: Development and Application in Aerobic Oxidative CH Amination at Room Temperature | |
| Department | OSSO国家重点实验室 |
Xie YJ(谢银君); Qian B(钱波); Jie P(解攀) ; Huang HM(黄汉民); Huang HM(黄汉民)
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| 2013 | |
| Source Publication | Advanced Synthesis and Catalysis
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| ISSN | 1615-4150 |
| Volume | 355Issue:7Pages:1315-1322 |
| Abstract | A conceptually new cooperative catalytic system via a synergistic combination of aldehyde and copper catalysis has been established based on systemic mechanistic studies. This new cooperative catalysis has been successfully applied in the direct aerobic oxidative C—H amination of azoles at room temperature, which was previously realized under harsh conditions. Mechanistic studies including isotopic labeling experiments and kinetic isotope effect (KIE) experiments support a reaction pathway that involves formation of an aminal, hydrolysis of the aminal to generate the copper-amide species, subsequent C—H amination and re-oxidation of copper(I) to copper(II) by oxygen. It not only provides an efficient method to realize the oxidative C—H amination of benzoxazoles with free amines at room temperature, but also paves the way for establishing new C—N bond formation reactions by using this efficient cooperative catalysis. |
| Keyword | Aldehydes C—h Amination Cooperative Catalysis Copper Room Temperature Reaction |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1002/adsc.201200944 |
| Funding Organization | the Chinese Academy of Sciences;the National Natural Science Foundation of China (21222203;21172226;21133011) |
| Indexed By | SCI |
| If | 5.542 |
| Language | 英语 |
| Funding Project | 有机功能材料研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4779 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Huang HM(黄汉民) |
| Affiliation | Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Xie YJ,Qian B,Jie P,et al. Cooperative Catalysis with Aldehydes and Copper: Development and Application in Aerobic Oxidative CH Amination at Room Temperature[J]. Advanced Synthesis and Catalysis,2013,355(7):1315-1322. |
| APA | Xie YJ,Qian B,Jie P,Huang HM,&黄汉民.(2013).Cooperative Catalysis with Aldehydes and Copper: Development and Application in Aerobic Oxidative CH Amination at Room Temperature.Advanced Synthesis and Catalysis,355(7),1315-1322. |
| MLA | Xie YJ,et al."Cooperative Catalysis with Aldehydes and Copper: Development and Application in Aerobic Oxidative CH Amination at Room Temperature".Advanced Synthesis and Catalysis 355.7(2013):1315-1322. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 1315.pdf（279KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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