Preparation, Characterization, and Drug-Release Behaviors of a pH-Sensitive Composite Hydrogel Bead Based on Guar Gum, Attapulgite, and Sodium Alginate

doi:10.1080/00914037.2012.706839

	Preparation, Characterization, and Drug-Release Behaviors of a pH-Sensitive Composite Hydrogel Bead Based on Guar Gum, Attapulgite, and Sodium Alginate
Department	环境材料与生态化学研究发展中心
	Yang HX(杨会霞)1,2; Wang WB(王文波)1 ; Zhang JP(张俊平)1 ; Wang AQ(王爱勤)1 ; Wang AQ(王爱勤)
	2013
Source Publication	International Journal of Polymeric Materials and Polymeric Biomaterials
ISSN	0091-4037
Volume	62 Issue:7 Pages:369-376
Abstract	A novel guar gum-g-poly (acrylic acid)/attapulgite/sodium alginate (GG-g-PAA/APT/SA) composite hydrogel bead with excellent pH sensitivity was prepared via a facile ionic gelation approach and characterized by FTIR and SEM techniques. The effect of APT content on the encapsulation efficiency (EE), swelling ratio, and drug release behaviors of the beads was investigated and the in-vitro release kinetics were also evaluated using diclofenac sodium (DS) as the model drug. The results indicate that the burst release effect of DS drug was eliminated due to the incorporation of APT, and the DS cumulative release was clearly decreased with increasing the APT content.
Keyword	Attapulgite Composite Hydrogel Bead Drug-release Behavior Guar Gum Ph-sensitive
Subject Area	功能复合材料
DOI	10.1080/00914037.2012.706839
Funding Organization	the National Natural Science Foundation of China (No. 51003112);the Science and Technology Support Project of Jiangsu Provincial Science & Tech. Department (No. BY2010012)
Indexed By	SCI
If	2.784
Language	英语
Funding Project	功能复合材料组
compositor	第一作者单位
Citation statistics	Cited Times:54[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/4533
Collection	环境材料与生态化学研究发展中心
Corresponding Author	Wang AQ(王爱勤)
Affiliation	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, R&D Ctr Xuyi Attapulgite Appl Technol, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Univ, Lanzhou 730000, Peoples R China
Recommended Citation GB/T 7714	Yang HX,Wang WB,Zhang JP,et al. Preparation, Characterization, and Drug-Release Behaviors of a pH-Sensitive Composite Hydrogel Bead Based on Guar Gum, Attapulgite, and Sodium Alginate[J]. International Journal of Polymeric Materials and Polymeric Biomaterials,2013,62(7):369-376.
APA	Yang HX,Wang WB,Zhang JP,Wang AQ,&王爱勤.(2013).Preparation, Characterization, and Drug-Release Behaviors of a pH-Sensitive Composite Hydrogel Bead Based on Guar Gum, Attapulgite, and Sodium Alginate.International Journal of Polymeric Materials and Polymeric Biomaterials,62(7),369-376.
MLA	Yang HX,et al."Preparation, Characterization, and Drug-Release Behaviors of a pH-Sensitive Composite Hydrogel Bead Based on Guar Gum, Attapulgite, and Sodium Alginate".International Journal of Polymeric Materials and Polymeric Biomaterials 62.7(2013):369-376.

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