| Spray-dried magnetic chitosan/Fe3O4/halloysite nanotubes/ofloxacin microspheres for sustained release of ofloxacin | |
| Department | 环境材料与生态化学研究发展中心 |
Wang Q(汪琴) ; Zhang JP(张俊平); Wang AQ(王爱勤); Zhang JP(张俊平)
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| 2013 | |
| Source Publication | RSC Advances
 |
| ISSN | 2046-2069 |
| Volume | 3Issue:45Pages:23423-23431 |
| Abstract | A series of magnetic chitosan/Fe3O4/halloysite nanotubes/ofloxacin (CTS/Fe3O4/HNTs/OFL) microspheres was prepared by spray-drying for the sustained release of OFL. CTS was in situ crosslinked by glutaraldehyde in the spray-drying process. The magnetic microspheres were characterized by FT-IR, scanning electron microscopy and thermogravimetric analysis. The magnetic properties, encapsulation efficiency, drug loading and in vitro sustained release properties of the magnetic microspheres for OFL were also evaluated. The CTS/Fe3O4/HNTs/OFL microspheres show superparamagnetic properties and fast magnetic response. The Fe3O4 nanoparticles have a remarkable effect on the surface morphology of the microspheres compared with HNTs. The encapsulation efficiency and the cumulative release are closely related to HNTs and Fe3O4 contents, crosslinking density and CTS concentration. OFL is released from the magnetic CTS/Fe3O4/HNTs/OFL microspheres via anomalous transport. |
| Subject Area | 功能复合材料 |
| DOI | 10.1039/c3ra43874k |
| Funding Organization | the National Natural Science Foundation of China (no. 51003112);the “Hundred Talents Program” of the Chinese Academy of Sciences |
| Indexed By | SCI |
| If | 3.708 |
| Language | 英语 |
| Funding Project | 功能复合材料组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4306 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | Zhang JP(张俊平) |
| Affiliation | Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Wang Q,Zhang JP,Wang AQ,et al. Spray-dried magnetic chitosan/Fe3O4/halloysite nanotubes/ofloxacin microspheres for sustained release of ofloxacin[J]. RSC Advances,2013,3(45):23423-23431. |
| APA | Wang Q,Zhang JP,Wang AQ,&张俊平.(2013).Spray-dried magnetic chitosan/Fe3O4/halloysite nanotubes/ofloxacin microspheres for sustained release of ofloxacin.RSC Advances,3(45),23423-23431. |
| MLA | Wang Q,et al."Spray-dried magnetic chitosan/Fe3O4/halloysite nanotubes/ofloxacin microspheres for sustained release of ofloxacin".RSC Advances 3.45(2013):23423-23431. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Spray-dried magnetic（729KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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