| In situ generation of sodium alginate/hydroxyapatite/halloysite nanotubes nanocomposite hydrogel beads as drug-controlled release matrices | |
| Department | 环境材料与生态化学研究发展中心 |
Fan L(范玲) ; Zhang JP(张俊平); Wang AQ(王爱勤); Zhang JP(张俊平)
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| 2013 | |
| Source Publication | Journal of Materials Chemistry B
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| ISSN | 2050-750X |
| Volume | 1Issue:45Pages:6261-6270 |
| Abstract | Diclofenac sodium-loaded sodium alginate/hydroxyapatite/halloysite nanotubes (SA/HA/HNTs–DS) nanocomposite hydrogel beads were prepared by the in situ generation of HA nanoparticles during the sol–gel transition of the SA/HNTs suspension. The nanocomposite beads were characterized by FT-IR spectroscopy, thermogravimetric analysis and field emission scanning electron microscopy, etc. Factors, e.g., the weight ratio of HNTs to SA (mHNTs/mSA), the weight ratio of (NH4)2HPO4 to SA (m(NH4)2HPO4/mSA), and the concentration of SA, which influenced the entrapment efficiency (EE) and release of DS, were investigated. The EE was enhanced from 62.85 ± 0.29% to 74.63 ± 1.65%, and the burst release of DS was overcome by introducing appropriate amounts of HA and HNTs. An almost constant rate release of DS is achieved when mHNTs/mSA ＝ 0.3 and m(NH4)2HPO4/mSA ＝ 0.1. The release rate of DS from the SA/HA/HNTs–DS beads was 9.19 mg g_1 h_1. The release of DS is controlled by Case-II transport. The tubular structure of the HNTs and the in situ-formed HA nanoparticles can restrict movability of the SA polymer chains, which is the main reason for the improved drug loading and release behavior. |
| Subject Area | 功能复合材料 |
| DOI | 10.1039/c3tb20971g |
| Funding Organization | the National Natural Science Foundation of China (no. 51003112);the “Hundred Talents Program” of the Chinese Academy of Sciences |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 功能复合材料组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4295 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | Zhang JP(张俊平) |
| Affiliation | Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Fan L,Zhang JP,Wang AQ,et al. In situ generation of sodium alginate/hydroxyapatite/halloysite nanotubes nanocomposite hydrogel beads as drug-controlled release matrices[J]. Journal of Materials Chemistry B,2013,1(45):6261-6270. |
| APA | Fan L,Zhang JP,Wang AQ,&张俊平.(2013).In situ generation of sodium alginate/hydroxyapatite/halloysite nanotubes nanocomposite hydrogel beads as drug-controlled release matrices.Journal of Materials Chemistry B,1(45),6261-6270. |
| MLA | Fan L,et al."In situ generation of sodium alginate/hydroxyapatite/halloysite nanotubes nanocomposite hydrogel beads as drug-controlled release matrices".Journal of Materials Chemistry B 1.45(2013):6261-6270. |
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| displayarticle.pdf（1119KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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