A general and facile one-pot process of isothiocyanates from amines under aqueous conditions | |
Department | OSSO国家重点实验室 |
Sun N(孙楠)1; Li B(黎滨)1; Shao JP(邵建平)1; Mo WM(莫卫民)1; Hu BX(胡宝祥)1; Shen ZL(沈振陆)1; Hu XQ(胡信全)1,2; Mo WM(莫卫民); Hu XQ(胡信全) | |
2012 | |
Source Publication | Beilstein Journal of Organic Chemistry |
ISSN | 1860-5397 |
Volume | 8Pages:61-70 |
Abstract | A general and facile one-pot protocol for the preparation of a broad range of alkyl and aryl isothiocyanates has been developed from their corresponding primary amines under aqueous conditions. This synthetic process involves an in situ generation of a dithiocarbamate salt from the amine substrate by reacting with CS2 followed by elimination to form the isothiocyanate product with cyanuric acid as the desulfurylation reagent. The choice of solvent is of decisive importance for the successful formation of the dithiocarbamate salt particularly for highly electron-deficient substrates. This novel and economical method is suitable for scale-up activities. |
Keyword | Aqueous Conditions Cyanuric Acid Isothiocyanates One-pot Process Organic Synthesis Primary Amines |
Subject Area | 物理化学与绿色催化 |
DOI | 10.3762/bjoc.8.6 |
Funding Organization | the National Natural Science Foundation of China (NSFC, 20772111;20876149);the project of Science and Technology Department of Zhejiang Province (2009C21013);the Natural Science Foundation of Zhejiang Province (Y407193) |
Indexed By | SCI |
If | 2.801 |
Language | 英语 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/3885 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Mo WM(莫卫民); Hu XQ(胡信全) |
Affiliation | 1.College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China 2.State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China |
Recommended Citation GB/T 7714 | Sun N,Li B,Shao JP,et al. A general and facile one-pot process of isothiocyanates from amines under aqueous conditions[J]. Beilstein Journal of Organic Chemistry,2012,8:61-70. |
APA | Sun N.,Li B.,Shao JP.,Mo WM.,Hu BX.,...&胡信全.(2012).A general and facile one-pot process of isothiocyanates from amines under aqueous conditions.Beilstein Journal of Organic Chemistry,8,61-70. |
MLA | Sun N,et al."A general and facile one-pot process of isothiocyanates from amines under aqueous conditions".Beilstein Journal of Organic Chemistry 8(2012):61-70. |
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B42.Beilstein J. Org(319KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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