| One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent | |
| Department | OSSO国家重点实验室 |
| Zhang G(张根)1; Zhang YH(张耀虎)1; Yan JX(闫洁熙)1; Chen R(陈茹)1; Wang SL(王守磊)1; Ma YX(马赟霞)1; Wang R(王锐)1,2; Wang R(王锐) | |
| 2012 | |
| Source Publication | the Journal of Organic Chemistry
 |
| ISSN | 0022-3263 |
| Volume | 77Issue:2Pages:878-888 |
| Abstract | Function-oriented design and synthesis of chiral small molecules with novel activity is a key goal in modern organic chemistry. As multiple antibiotic-resistant pathogens are emerging and causing serious diseases, the need for practical routes for the development of new types of antibacterial agents is very urgent. Herein, we present a highly efficient process for the synthesis of optically active pyranocoumarins and 2-amino-4H-chromenes through an organocatalytic Knoevenagel/Michael/cyclization sequence, and the preliminary biological studies of these new heterocyclic compounds revealed potent antibacterial activity. This study provides a novel strategy for further research and development of new types of antibacterial agents effective against human pathogens. |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1021/jo202020m |
| Funding Organization | the National Natural Science Foundation of China (No. 90813012;20932003);the Key National S & T Program “Major New Drug Development” of the Ministry of Science and Technology (2012ZX09504001-003) |
| Indexed By | SCI |
| If | 4.564 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/3836 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Wang R(王锐) |
| Affiliation | 1.Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Inst Biochem & Mol Biol, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang G,Zhang YH,Yan JX,et al. One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent[J]. the Journal of Organic Chemistry,2012,77(2):878-888. |
| APA | Zhang G.,Zhang YH.,Yan JX.,Chen R.,Wang SL.,...&王锐.(2012).One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent.the Journal of Organic Chemistry,77(2),878-888. |
| MLA | Zhang G,et al."One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent".the Journal of Organic Chemistry 77.2(2012):878-888. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 57.J. Org. Chem., 20（485KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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