| A novel magnetic triple-responsive composite semi-IPN hydrogels for targeted and controlled drug delivery | |
| Department | 固体润滑国家重点实验室 |
Huang YJ(黄银娟)1; Liu MZ(刘明柱)1; Chen JC(陈久存)1; Gao CM(高春美)1; Gong QY(龚秋雨)2 ; Liu MZ(刘明柱)
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| 2012 | |
| Source Publication | European Polymer Journal
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| ISSN | 0014-3057 |
| Volume | 48Issue:10Pages:1734-1744 |
| Abstract | In this work, Fe3O4/poly(3-acrylamidephenylboronic acid-co-(2-dimethylamino) ethyl methacrylate) (Fe3O4/P(AAPBA-co-DMAEMA)) hydrogels possessing magnetic and triple-responsive properties and semi-interpenetrated by β-cyclodextrin-epichlorohydrin (β-CD-EPI) were prepared via radical polymerization. The characteristics of the materials have been investigated by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM). The swelling measurements and the application of Fe3O4/P(AAPBA-co-DMAEMA)/(β-CD-EPI) hydrogels in controlled release of drug were also investigated. It was found that the magnetic hydrogels exhibit swelling behaviors affected by pH, temperature, glucose concentration and magnetic field, and have porous morphologies, superparamagnetism. Moreover, the hydrogels possess targeting and could control the release of quercetin by adjusting pH value, temperature, glucose concentration and magnetic field. |
| Keyword | 2-(DimEthylamino) Ethyl Methacrylate 3-acrylamide Phenylboronic Acid Hydrogels Triple-responsive Fe3o4 Targeted |
| Subject Area | 材料科学与物理化学 |
| DOI | 10.1016/j.eurpolymj.2012.06.012 |
| Funding Organization | the Special Doctorial Program Funds of the Education of China (Grant No.: 20090211110004);Gansu Province Project of Science and Technologies (Grant No.: 0804WCGA130) |
| Indexed By | SCI |
| If | 2.562 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/3337 |
| Collection | 固体润滑国家重点实验室（LSL） |
| Corresponding Author | Liu MZ(刘明柱) |
| Affiliation | 1.Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China 2.Key Laboratory of Solid Lubrication, Chinese Academy of Sciences, Lanzhou Institute of Chemical Physics, Lanzhou 730000, PR China |
| Recommended Citation GB/T 7714 | Huang YJ,Liu MZ,Chen JC,et al. A novel magnetic triple-responsive composite semi-IPN hydrogels for targeted and controlled drug delivery[J]. European Polymer Journal,2012,48(10):1734-1744. |
| APA | Huang YJ,Liu MZ,Chen JC,Gao CM,Gong QY,&刘明柱.(2012).A novel magnetic triple-responsive composite semi-IPN hydrogels for targeted and controlled drug delivery.European Polymer Journal,48(10),1734-1744. |
| MLA | Huang YJ,et al."A novel magnetic triple-responsive composite semi-IPN hydrogels for targeted and controlled drug delivery".European Polymer Journal 48.10(2012):1734-1744. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 1734-1744.PDF（1168KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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