| (±)-Ferulasin, Unusual Sesquiterpene Chromones from Ferula sinkiangensis | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Jia-Lin Wang1; Xian-Hua Meng2; Yi-Dan Zheng3; Chun-Yan Sang2; Wei-Feng Wang2; Jun-Yi Ma3; Thi-Kim-Quy Ha4; Ya-Min Zhao1; Jun-Li Yang2
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| The second department | 药物化学与新药分子研究团队 |
| 2022 | |
| Source Publication | Tetrahedron
 |
| Issue | 122Pages:132953 |
| Abstract | Two unreported sesquiterpene chromones, (±)-ferulasin (1), were isolated from the roots of Ferula sinkiangensis. Ferulasin (1) shows one uncommon oxygen-containing macrocyclic structure with one trioxaspiro, and represents a new framework in which the side chain sesquiterpene C-100 and C-110 form an oxygen-containing 13-membered ring with chromone C-2. The chemical structure was established by diverse spectroscopic methods, X-ray crystallographic analyses and ECD calculations. (±)-Ferulasin (1) exhibited potent cytotoxicity against pancreatic cancer cells with IC50 values ranging from 0.92 ± 0.12 to 19.13 ± 2.99 mM. |
| DOI | 10.1016/j.tet.2022.132953 |
| If | 2.388 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/29277 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Ya-Min Zhao; Jun-Li Yang |
| Affiliation | 1.College of Chemical Engineering, Experimental Teaching Department, Northwest Minzu University 2.Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS) 3.College of Life Science, Northwest Normal University 4.Department of Chemistry, College of Natural Sciences, Can Tho University |
| Recommended Citation GB/T 7714 | Jia-Lin Wang,Xian-Hua Meng,Yi-Dan Zheng,et al. (±)-Ferulasin, Unusual Sesquiterpene Chromones from Ferula sinkiangensis[J]. Tetrahedron,2022(122):132953. |
| APA | Jia-Lin Wang.,Xian-Hua Meng.,Yi-Dan Zheng.,Chun-Yan Sang.,Wei-Feng Wang.,...&Jun-Li Yang.(2022).(±)-Ferulasin, Unusual Sesquiterpene Chromones from Ferula sinkiangensis.Tetrahedron(122),132953. |
| MLA | Jia-Lin Wang,et al."(±)-Ferulasin, Unusual Sesquiterpene Chromones from Ferula sinkiangensis".Tetrahedron .122(2022):132953. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2022-Tetrahedron-(?)（698KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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