Chemical constituents from the roots of Zanthoxylum bungeanum Maxim. and their neuroprotective activities | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Li-Mei Ma1,2; Cheng-Bo Wang1; Xiao-Xue Zhai3; Kai Wang1,2; Chun-Yan Sang1; Wei-Feng Wang1,4; Jun Wang4; Jun-Li Yang1 | |
The second department | 药物化学与新药分子研究团队 |
2022 | |
Source Publication | Fitoterapia |
Issue | 163Pages:105337 |
Abstract | Twenty-two isolates, including two previously undescribed compounds identified as benzoyltembamide (1) and P-benzoyphenethyl anisate (21), were isolated and identified from a methanol extract of the roots of Zanthoxylum bungeanum Maxim. (Rutaceae) using diverse chromatographic materials and pre-HPLC. Their structures were elucidated on the basis of spectroscopic and spectrometric data analysis such as HR-ESI-MS, 1D and 2D NMR, IR and UV, as well as single-crystal X-ray diffraction for crystalline compounds. All the compounds (except for compound 16) were isolated from the roots of Z. bungeanum for the first time. Selected compounds were evaluated for their antioxidant activities. Compound 18 attenuated the H2O2-induced cytotoxicity and blocked the accumulation of ROS in SH-SY5Y cells, and exhibited potent neuroprotective activity. |
Keyword | Chemical constituents Neuroprotective activities Rutaceae Zanthoxylum bungeanum Maxim |
If | 3.204 |
compositor | 第一作者单位 |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/29261 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Jun Wang; Jun-Li Yang |
Affiliation | 1.Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS) 2.University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS) 3.College of Chemical Engineering, Northwest Minzu University 4.Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing |
Recommended Citation GB/T 7714 | Li-Mei Ma,Cheng-Bo Wang,Xiao-Xue Zhai,et al. Chemical constituents from the roots of Zanthoxylum bungeanum Maxim. and their neuroprotective activities[J]. Fitoterapia,2022(163):105337. |
APA | Li-Mei Ma.,Cheng-Bo Wang.,Xiao-Xue Zhai.,Kai Wang.,Chun-Yan Sang.,...&Jun-Li Yang.(2022).Chemical constituents from the roots of Zanthoxylum bungeanum Maxim. and their neuroprotective activities.Fitoterapia(163),105337. |
MLA | Li-Mei Ma,et al."Chemical constituents from the roots of Zanthoxylum bungeanum Maxim. and their neuroprotective activities".Fitoterapia .163(2022):105337. |
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2022 Fitoterapia Che(1271KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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