Tabersonine inhibits the lipopolysaccharide induced neuroinflammatory response in BV2 microglia cells via the NF-κB signaling pathway | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Jiao-Tai Shi1; Cheng-Bo Wang2; Chun-Yan Sang2; Stanislas Nsanzamahoro2,3; Tian Chai2; Jun Wang4; Ai-Mei Yang1; Jun-Li Yang2 | |
The second department | 药物化学与新药分子研究团队 |
2022 | |
Source Publication | Molecules |
Issue | 27Pages:7521 |
Abstract | The occurrence and development of neurodegenerative diseases is related to a variety of physiological and pathological changes. Neuroinflammation is one of the major factors that induces and aggravates neurodegenerative diseases. The most important manifestation of neuroinflammation is the activation of microglia. Therefore, inhibiting the abnormal activation of microglia is an important way to alleviate the occurrence of neuroinflammatory diseases. In this research, the inhibitory effect of tabersonine (Tab) on neuroinflammation was evaluated by establishing the BV2 neuroinflammation model induced by lipopolysaccharide (LPS). It was found that Tab significantly inhibited the production and expression of nitric oxide (NO), interleukin-1b (IL-1b), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and reactive oxygen species (ROS) in BV-2 cells stimulated by LPS. In addition, Tab can also inhibit the activation of nuclear factor-kB (NF- κ B) induced by LPS, thus regulating inflammatory mediators such as inducible nitric oxide synthase (iNOS). These results indicated that Tab regulated the release of inflammatory mediators such as NO, IL-1b, TNF-_, and IL-6 by inhibiting NF-kB signaling pathway, and exerting its anti-neuroinflammatory effect. This is the first report regarding the inhibition on LPS-induced neuroinflammation in BV2 microglia cells of Tab, which indicated the drug development potential of Tab for the treatment of neurodegenerative diseases. |
Keyword | tabersonine neuroinflammation lipopolysaccharide BV2 NF-kB signaling pathway |
DOI | 10.3390/molecules27217521 |
If | 4.927 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/29254 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Ai-Mei Yang; Jun-Li Yang |
Affiliation | 1.School of Life Science and Engineering, Lanzhou University of Technology 2.Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences 3.University of Chinese Academy of Sciences 4.Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing |
Recommended Citation GB/T 7714 | Jiao-Tai Shi,Cheng-Bo Wang,Chun-Yan Sang,et al. Tabersonine inhibits the lipopolysaccharide induced neuroinflammatory response in BV2 microglia cells via the NF-κB signaling pathway[J]. Molecules,2022(27):7521. |
APA | Jiao-Tai Shi.,Cheng-Bo Wang.,Chun-Yan Sang.,Stanislas Nsanzamahoro.,Tian Chai.,...&Jun-Li Yang.(2022).Tabersonine inhibits the lipopolysaccharide induced neuroinflammatory response in BV2 microglia cells via the NF-κB signaling pathway.Molecules(27),7521. |
MLA | Jiao-Tai Shi,et al."Tabersonine inhibits the lipopolysaccharide induced neuroinflammatory response in BV2 microglia cells via the NF-κB signaling pathway".Molecules .27(2022):7521. |
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2022 Molecules Taber(2436KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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