羰基合成与选择氧化国家重点实验室（OSSO）知识库

An efficient synthesis of amino-substituted isoquinolines
via Rh(III)-catalyzed oxidative [2+2+2] annulation of pyridines with
alkynes has been developed, which is cooperatively enabled by a directing
carbonyl and steric hindrance adjacent to the amino group of the
pyridine, via a six-membered rhodacyclic intermediate without coordination
with the pyridinic nitrogen. The establishment of this C–H activation
strategy also paves the way for other oxidative transformations
of heterocyclic C–H bonds.