Ingenane and jatrophane diterpenoids from Euphorbia kansui and their antiproliferative effects

doi:doi.org/10.1016/j.phytochem.2020.112257

LICP OpenIR > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Ingenane and jatrophane diterpenoids from Euphorbia kansui and their antiproliferative effects
Department	中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
	Meng XH(孟宪华)1; Wang K(王凯)1,2; Chai T(柴甜)1; Zhi-YingGuo 3; Zhao M(赵名)4; Yang JL(杨军丽)1
The second department	505t组
	2020
Source Publication	Phytochemistry
Volume	172 Issue:-Pages:112257
Abstract	In this study, fourteen ingenane-type and nine jatrophane-type diterpenoids were isolated from Euphorbia kansui, including seven undescribed compounds. Kansuingenol A-C have the 6,7-vicinal diol moiety, and Kansuijatrophanol A and B possess the 11,12-vicinal diol moiety, both of which are rarely reported. 3,4-(Methylenedioxy) cinnamyl moiety was found for the first time in jatrophane-type diterpenoids, as shown in Kansuijatrophanol C and D. The absolute configurations of seven undescribed compounds have been analyzed and assigned by the modified Mosher's method, Mo₂(OAc)₄-induced circular dichroism (ICD) method, and CD exciton chirality method. All compounds were screened for their antiproliferative effects against HepG2, MCF-7 and DU145 cell lines. Regarding the HepG2 cells, Kansuijatrophanol C exhibited the most promising inhibition with the IC₅₀ value of 9.47 ± 0.31 μM. Regarding the MCF-7 and DU145 cells, Kansuijatrophanol D exhibited the most promising inhibition with the IC₅₀ values of 6.29 ± 0.18 and 4.19 ± 0.32 μM, respectively.
Keyword	Euphorbia kansui Euphorbiaceae Diterpenoid Ingenane Jatrophane HepG2 cell lines MCF-7 cell lines DU145 cell lines
MOST Discipline Catalogue	理学::化学
DOI	doi.org/10.1016/j.phytochem.2020.112257
Indexed By	SCI
If	3.044
Language	英语
compositor	第一作者单位
Citation statistics
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/26523
Collection	中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
Corresponding Author	Meng XH(孟宪华)
Affiliation	1.Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences 2.University of Chinese Academy of Sciences 3.National Center of Biomedical Analysis 4.Institute of Cognition and Brain Sciences
Recommended Citation GB/T 7714	Meng XH,Wang K,Chai T,et al. Ingenane and jatrophane diterpenoids from Euphorbia kansui and their antiproliferative effects[J]. Phytochemistry,2020,172(-):112257.
APA	Meng XH,Wang K,Chai T,Zhi-YingGuo,Zhao M,&Yang JL.(2020).Ingenane and jatrophane diterpenoids from Euphorbia kansui and their antiproliferative effects.Phytochemistry,172(-),112257.
MLA	Meng XH,et al."Ingenane and jatrophane diterpenoids from Euphorbia kansui and their antiproliferative effects".Phytochemistry 172.-(2020):112257.

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