Wolfberry extracts inhibit Aˇ1-42aggregation and rescue memory lossof AD drosophila | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Li CH(李彩虹)1,2; Yang JL(杨军丽)1 | |
The second department | 505t |
2020 | |
Source Publication | Food Science and Human Wellness |
Volume | 9Issue:1Pages:64–70 |
Abstract | This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease (AD) and the relationship between their anti-AD property and the geographic locations in China. Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ1-42 aggregation and Cu2+-induced Aβ1-42 aggregation and the antioxidant capacity as well as the bioactivity for binding bio-metal. A transgenic drosophila model assay revealed that TE of S1 and S6 (S1-TE and S6-TE) at 100 μg/mL demonstrated the potent rescue effect on memory loss compared to the positive control memantine at 20 μg/mL. Further study also revealed the polysaccharide extracts could contribute to their anti-AD property, and the anti-AD activity conspicuously depends on growing environment. Wolfberry samples S1 and S6 showed much more potent anti-AD property. Meanwhile this study demonstrated that the Chinese commonly consumed wolfberry in boiling water might have the beneficial function to prevent AD pathology. |
Keyword | Aˇ1−42 Antioxidant bioactivity Anti-AD potential Bio-metal Drosophila Wolfberry |
MOST Discipline Catalogue | 理学::化学 |
DOI | doi.org/10.1016/j.fshw.2019.12.007 |
Indexed By | SCI |
If | 2.455 |
Language | 英语 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/26516 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Yang JL(杨军丽) |
Affiliation | 1.Lanzhou Institute ofChemical Physics (LICP), Chinese Academy of Sciences (CAS) 2.ChinabUniversity of Chinese Academy of Sciences |
Recommended Citation GB/T 7714 | Li CH,Yang JL. Wolfberry extracts inhibit Aˇ1-42aggregation and rescue memory lossof AD drosophila[J]. Food Science and Human Wellness,2020,9(1):64–70. |
APA | Li CH,&Yang JL.(2020).Wolfberry extracts inhibit Aˇ1-42aggregation and rescue memory lossof AD drosophila.Food Science and Human Wellness,9(1),64–70. |
MLA | Li CH,et al."Wolfberry extracts inhibit Aˇ1-42aggregation and rescue memory lossof AD drosophila".Food Science and Human Wellness 9.1(2020):64–70. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
FSHW Wolfberry extra(2431KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment