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非水相脂肪酶催化氟比洛芬维c酯的合成及条件优化
Alternative TitleLipase-catalyzed Synthesis of Flurbiprofen VC Ester
张宏迪1; 辛嘉英1; 孙立瑞1; 马惠琳1; 夏春谷2
2019
Source Publication分子催化
ISSN1001-3555
Volume33Issue:4Pages:323-330
Abstract采用非水相酶催化法合成氟比洛芬维生素C酯,使用高效液相色谱和质谱等方法对产物结构进行了表征.同时构建非水相反应体系,通过研究确定最优合成条件:在10 mL、0.057 mol/L的叔丁醇维生素C溶液中,分别添加2.84 mmol氟比洛芬甲酯,10%的N435脂肪酶(以底物的质量分数计),0.8 g分子筛,在70 ℃,200 r/min的条件下反应28 h.最优条件下的产物转化率为73.63%.
Indexed ByCSCD
Language中文
Citation statistics
Cited Times:3[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.licp.cn/handle/362003/26277
Collection中国科学院兰州化学物理研究所
Affiliation1.哈尔滨商业大学
2.中国科学院兰州化学物理研究所
Recommended Citation
GB/T 7714		 张宏迪,辛嘉英,孙立瑞,等. 非水相脂肪酶催化氟比洛芬维c酯的合成及条件优化[J]. 分子催化,2019,33(4):323-330.
APA 张宏迪,辛嘉英,孙立瑞,马惠琳,&夏春谷.(2019).非水相脂肪酶催化氟比洛芬维c酯的合成及条件优化.分子催化,33(4),323-330.
MLA 张宏迪,et al."非水相脂肪酶催化氟比洛芬维c酯的合成及条件优化".分子催化 33.4(2019):323-330.
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