Dammarane-type Saponins from Gynostemma pentaphyllum and Their Potential anti-AD Activity | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Jun Wang1,2; Cai-Hong Li1,2; Mahdi Moridi Farimani3; Jun-Li Yang1 | |
The second department | 505t |
2019-03 | |
Source Publication | Phytochemistry Letters |
Volume | 31Issue:-Pages:147–154 |
Abstract | To search for potential candidate anti-AD agents, the gypenosideson the aerial parts of Gynostemma pentaphyllum were phytochemically investigated, yielding two undescribed (1-2) and five known (3-7) dammarane saponins. Their molecular structures were unambiguously elucidated via spectroscopic analyses (1D and 2D NMR, HR-ESI-MS, IR, and optical rotation) chemical transformations. All of the compounds possessed a 21-O-n-butyl-20,21-dihydroxy-21,23-epoxydammar-24-ene moiety in their structures. The short-term memory assay on a transgenic fly Alzheimer’s disease (AD) model revealed that all of the compounds displayed potential anti-AD activity. Of the compounds, 1 and 6 at 10 μM showed comparable short-term memory rescue ability to memantine, the positive control, at 100 μM. This study revealed the potent antagonistic effect of dammarane-type saponins 1 and 6 against Alzheimer’s disease. |
Keyword | Gynostemma pentaphyllum Dammarane-type saponins Alzheimer’s disease |
MOST Discipline Catalogue | 理学::化学 |
DOI | doi.org/10.1016/j.phytol.2019.03.022 |
Indexed By | SCI |
If | 1.338 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/25445 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Jun-Li Yang |
Affiliation | 1.Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences (CAS) 2.Shahid Beheshti University 3.University of Chinese Academy of Sciences, Chinese Academy of Sciences |
Recommended Citation GB/T 7714 | Jun Wang,Cai-Hong Li,Mahdi Moridi Farimani,et al. Dammarane-type Saponins from Gynostemma pentaphyllum and Their Potential anti-AD Activity[J]. Phytochemistry Letters,2019,31(-):147–154. |
APA | Jun Wang,Cai-Hong Li,Mahdi Moridi Farimani,&Jun-Li Yang.(2019).Dammarane-type Saponins from Gynostemma pentaphyllum and Their Potential anti-AD Activity.Phytochemistry Letters,31(-),147–154. |
MLA | Jun Wang,et al."Dammarane-type Saponins from Gynostemma pentaphyllum and Their Potential anti-AD Activity".Phytochemistry Letters 31.-(2019):147–154. |
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PhytoL_Dammarane-typ(2262KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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