| pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium | |
| Department | 环境材料与生态化学研究发展中心 |
Hua SB(华水波)1,2; Yang HX(杨会霞)1,2; Li Q(李琼)3; Zhang JP(张俊平)1 ; Wang AQ(王爱勤)1; Wang AQ(王爱勤)
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| 2012 | |
| Source Publication | Drug Development and Industrial Pharmacy
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| ISSN | 0363-9045 |
| Volume | 38Issue:6Pages:728-734 |
| Abstract | Objective: The aim of this study was to prepare pH-sensitive sodium alginate/calcined hydrotalcite (SA/CHT) hybrid bead with improved the burst release effect of the drug. Materials and methods: A series of pH-sensitive SA/CHT hybrid beads were prepared by using Ca2+ cross-linking in the presence of diclofenac sodium (DS) and SA. The structure and drug loading of the beads were characterized by Fourier transform infrared spectroscopy and X-ray diffraction. The swelling and the drug release of the fabricated beads were investigated by the pH of test medium and CHT content. Result: The formed positively charged hydrotalcite layers were adsorbed on the negatively charged SA polymer chains through electrostatic interaction and act as inorganic cross-linkers in the three-dimensional network. Compared to pure SA beads, the incorporation of CHT enhanced the drug encapsulation efficiency, improved the swelling behaviors and slowed the drug release from the hybrid beads. Discussion and conclusions: The electrostatic interaction between hydrotalcite and SA has restricted the movability of the SA polymer chains, and then slowed down swelling and dissolution rates in aqueous solutions. The results provided a simple method to moderate drug release and matrix degradation of the SA beads. |
| Keyword | Bead Alginate Hydrotalcite Drug Release Diclofenac Sodium |
| Subject Area | 环境材料与生态化学 |
| DOI | 10.3109/03639045.2011.623702 |
| Funding Organization | the National Natural Science Foundation of China (No. 51003112);the Special Research Fund of Scholarship of Dean of CAS |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 功能复合材料组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/2534 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | Wang AQ(王爱勤) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Hua SB,Yang HX,Li Q,et al. pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium[J]. Drug Development and Industrial Pharmacy,2012,38(6):728-734. |
| APA | Hua SB,Yang HX,Li Q,Zhang JP,Wang AQ,&王爱勤.(2012).pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium.Drug Development and Industrial Pharmacy,38(6),728-734. |
| MLA | Hua SB,et al."pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium".Drug Development and Industrial Pharmacy 38.6(2012):728-734. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2012386718734.pdf（868KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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