| Sesquiterpenoids from Ligularia virgaurea spp. Oligocephala | |
| Department | 甘肃省天然药物重点实验室 |
Wu QX(武全香); Yang AM(杨爱梅); Shi YP(师彦平)
| |
| 2005 | |
| Source Publication | Tetrohedron
 |
| ISSN | 0040-4020 |
| Volume | 61Pages:10529–10535 |
| Abstract | Four novel eremophilane-type sesquiterpene lactones, 6b,10a-dihydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (1), 6b-acetyl-2-oxoeremophila-1(10),7(11), 8(9)-trien-12,8-olide (2), 6b,8b-diacetyl-2 oxoeremophila-1(10),7(11)-dien-12,8-olide (3), dimeric eremophilane ligulolide B (5), and known sesquiterpenoid, 6b,8a-diacetyleremophila-1(10),7(11)-dien-12,8-olide (4), were isolated from an extract of the whole plant of Ligularia virgaurea spp. oligocephala. The structure of 1 was confirmed by NMR spectra and single crystal X-ray crystallography investigation, as well as 2, 3, and 5 were elucidated by spectroscopic methods including 1D and 2D NMR spectra. A discussion of biogenesis of 5 was described. Cytotoxicities of compound 1 were measured in vitro against selected cancer cells human promyelocytic leukemia (HL-60), human ovarian (HO-8910) and human lung epithehial (A-549). |
| Keyword | Ligularia Virgaurea Spp. Oligocephala Sesquiterpenoids Eremophilane |
| Subject Area | 分析化学 ; 药物化学 |
| Funding Organization | the National Natural Science Foundation of China (NSFC 20021001;20372029;20475057) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 抗糖尿病中药古方活性组份的发现及其高效液相色谱-质谱联用仪系统性研究 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/2498 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Shi YP(师彦平) |
| Recommended Citation GB/T 7714 | Wu QX,Yang AM,Shi YP. Sesquiterpenoids from Ligularia virgaurea spp. Oligocephala[J]. Tetrohedron,2005,61:10529–10535. |
| APA | 武全香,杨爱梅,&师彦平.(2005).Sesquiterpenoids from Ligularia virgaurea spp. Oligocephala.Tetrohedron,61,10529–10535. |
| MLA | 武全香,et al."Sesquiterpenoids from Ligularia virgaurea spp. Oligocephala".Tetrohedron 61(2005):10529–10535. |
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