| The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals | |
| Department | 羰基合成与选择氧化国家重点实验室 |
| Gong P(龚频); Chen FX(陈福欣); Zhao QY(赵乾宇); Ma GF(马国芬); Wang R(王锐) | |
| 2009 | |
| Source Publication | Journal of Peptide Science
 |
| ISSN | 1075-2617 |
| Volume | 15Pages:337-344 |
| Abstract | Endomorphin 1 (EM1), an endogenous μ-opioid receptor agonist, acts as a free radical scavenger in vitro and an antioxidant in vivo. The modification of EM1 by ROS and the properties of the OM attracted our attention. In vitro assays were performed via RP-HPLC, spectrophotometric measurements, EPR and amino acid analysis, Schmorl’s reaction to define the formation of melanin-like compounds transformed from EM1, collectively namedEM1–melanin and by solubility assay, radioligand-binding assay, NADH oxidation, superoxide anion scavenging assay to study some physical and chemical properties of EM1–melanin. Possible pathways of the formation of EM1–melanin were proposed. |
| Keyword | Endomorphin 1 Ros Em1–melanin Oxidative Metabolite |
| Subject Area | 物理化学 |
| Funding Organization | the National Natural Science Foundation of China (Nos. 20525206;20621091;20772052);the Specialized Research Fund for the Doctoral Program in Higher Education Institutions of the Ministry of Education of China |
| Indexed By | SCI |
| Language | 英语 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/2310 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Wang R(王锐) |
| Recommended Citation GB/T 7714 | Gong P,Chen FX,Zhao QY,et al. The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals[J]. Journal of Peptide Science,2009,15:337-344. |
| APA | 龚频,陈福欣,赵乾宇,马国芬,&王锐.(2009).The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals.Journal of Peptide Science,15,337-344. |
| MLA | 龚频,et al."The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals".Journal of Peptide Science 15(2009):337-344. |
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| File Name/Size | DocType | Version | Access | License | ||
| B38_J.Pept.Sci.,2009（249KB） | 开放获取 | License | View Application Full Text | |||
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